Results 61 to 70 of about 154,223 (263)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Macular and Functional Outcomes After Secondary IOL Implantation Using the Yamane Technique in Aphakia, IOL Subluxation, and IOL Dislocation

Clinical Ophthalmology
Giacomo Visioli,1,2,* Giuseppe Maria Albanese,1,3,* Silvia Magherini,1 Daniele Cappiello,1 Carmen Baratta,1 Marta Armentano,1 Luca Lucchino,1 Ludovico Iannetti,4 Magda Gharbiya1,4 1Department of Sense Organs - Sapienza University of Rome,
Visioli G, Albanese GM, Magherini S, Cappiello D, Baratta C, Armentano M, Lucchino L, Iannetti L, Gharbiya M   +8 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Ocular Manifestations of Perinatal HIV Infection in Kenyan Children on HAART: A Cross-Sectional Comparative Study

Clinical Ophthalmology
Ludovico Alisi,1,2,* Marta Armentano,1,2,* Giacomo Visioli,1 Mpekethu Sam Mingaine,3 Giuseppe Maria Albanese,1 Luca Lucchino,1 Alice Bruscolini1 1Department of Sense Organs, Sapienza University of Rome, Rome, Italy; 2AINA Children’s Home,
Alisi L, Armentano M, Visioli G, Mingaine MS, Albanese GM, Lucchino L, Bruscolini A   +6 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Nanophotonics for Organic Material Sensing

Asia Communications and Photonics Conference, 2012
Metamaterial surfaces that exploit nanophotonic techniques are now being widely explored for applications in the sensing of organic materials. Our presentation will explore localisation and sensitivity issues for resonant structures.
De La Rue, Richard M., Lahiri, Basudev, Sharp, Graham, McMeekin, Scott G., Johnson, Nigel P.   +4 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Cross-Cultural Adaptation and Validation of the Listening Inventory for Education-Revised in Italian

Audiology Research
Background: Listening difficulties may frequently occur in school settings, but so far there were no tools to identify them for both hearing and hearing-impaired Italian students.
Maria Nicastri, Hilal Dincer D’Alessandro, Karen Anderson, Miriana Ciferri, Luca Cavalcanti, Antonio Greco, Ilaria Giallini, Ginevra Portanova, Patrizia Mancini   +8 more
doaj   +1 more source