Results 71 to 80 of about 814,534 (292)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Role of spatial averaging in multicellular gradient sensing

, 2015
Gradient sensing underlies important biological processes including morphogenesis, polarization, and cell migration. The precision of gradient sensing increases with the length of a detector (a cell or group of cells) in the gradient direction, since a ...
Fancher, Sean, Levchenko, Andre, Mugler, Andrew, Nemenman, Ilya, Smith, Tyler   +4 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Quantum dynamics of the avian compass

, 2014
The ability of migratory birds to orient relative to the Earth's magnetic field is believed to involve a coherent superposition of two spin states of a radical electron pair. However, the mechanism by which this coherence can be maintained in the face of
C. D. Treiber, G. Woodgate, K. Blum, M. A. Schlosshauer, R. Muheim, R. Muheim, Z. Walters, Zachary B. Walters   +7 more
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Optimization of TiO2 and PMAPTAC Concentrations of a Chemical Humidity Sensing Mechanism

Sensors, 2009
This work aims to achieve an optimization of the TiO2 and PMAPTAC concentrations in a chemical resistive-type humidity sensing mechanism (RHSM). Our idea is based primarily on the modeling of the sensing mechanism.
Samir Barra, Abdelghani Dendouga, Souhil Kouda, Zohir Dibi, Fayçal Meddour   +4 more
doaj   +1 more source

Screening of Indonesia Medicinal Plants Producing Quorum Sensing Inhibitor [PDF]

, 2011
Antibiotic resistance of bacteria lead to create different way in the pathogen bacteria handling such us inhibit their quorum sensing mechanism. The goal of this study is to search quorum sensing inhibitor of seven Indonesia medicinal plants.
Artadana, Ida Bagus Made, Kok, Tjie, Liana, Anny, Prilianti, Kestrilia Rega, Putra, Sulistyo Emantoko Dwi, Rusady, Hendry, Savitri, Savitri, Suryadjaja, Ernest   +7 more
core  

CENTURION: Incentivizing Multi-Requester Mobile Crowd Sensing

, 2017
The recent proliferation of increasingly capable mobile devices has given rise to mobile crowd sensing (MCS) systems that outsource the collection of sensory data to a crowd of participating workers that carry various mobile devices.
Jin, Haiming, Nahrstedt, Klara, Su, Lu
core   +1 more source