Results 81 to 90 of about 814,534 (292)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Recoverable Detection of Dichloromethane by MEMS Gas Sensor Based on Mo and Ni Co-Doped SnO₂ Nanostructure

Sensors
The challenging problem of chlorine “poisoning” SnO2 for poorly recoverable detection of dichloromethane has been solved in this work. The materials synthesized by Ni or/and Mo doping SnO2 were spread onto the micro-hotplates (
Mengxue Xu, Yihong Zhong, Hongpeng Zhang, Yi Tao, Qingqing Shen, Shumin Zhang, Pingping Zhang, Xiaochun Hu, Xingqi Liu, Xuhui Sun, Zhenxing Cheng   +10 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A Mini-Review on Metal Oxide Semiconductor Gas Sensors for Carbon Monoxide Detection at Room Temperature

Chemosensors
Carbon monoxide can cause severe harm to humans even at low concentrations. Metal Oxide Semiconductor (MOS) carbon monoxide gas sensors have excellent sensing performance regarding sensitivity, selectivity, response speed, and stability, making them very
Yaoyi He, Mingzhi Jiao
doaj   +1 more source

Tuning the exponential sensitivity of a bound-state-in-continuum optical sensor. [PDF]

, 2019
In this work, we investigate the evanescent field sensing mechanism provided by an all-dielectric metasurface supporting bound states in the continuum (BICs). The metasurface is based on a transparent photonic crystal with subwavelength thickness.
Cabrini, Stefano, Coppola, Giuseppe, Lara Yépez, Sofía N, Mocellaark, Vito, Penzo, Erika, Rendina, Ivo, Romano, Silvia, Zito, Gianluigi   +7 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Innovative Microfluidic Technologies for Rapid Heavy Metal Ion Detection

Chemosensors
Heavy metal ion (HMI) contamination poses significant threats to public health and environmental safety, necessitating advanced detection technologies that are rapid, sensitive, and field-deployable.
Muhammad Furqan Rauf, Zhenda Lin, Muhammad Kamran Rauf, Jin-Ming Lin   +3 more
doaj   +1 more source