Results 131 to 140 of about 3,965,120 (318)
Cost-Sensitive Decision Tree with Multiple Resource Constraints [PDF]
Resource constraints are commonly found in classification tasks. For example, there could be a budget limit on implementation and a deadline for finishing the classification task.
Chia-Chi WU, Kwei TANG, Yen-Liang CHEN
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Scouting Context-sensitive Components [PDF]
, 2001 Nature's gadgets are implemented without being planned and therefore can utilize context-sensitive components. Thus functionality that would require extensive networks of context-free components can be elicited from a minimum of material.
Pfaffmann, J. O., Zauner, K.-P.
core
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Do Sensitive Products Undermine Ambition? [PDF]
The long-running WTO negotiations remain unresolved. Agriculture is the main stumbling block. Members have agreed to linear tariff reductions within bands, but proposed exemptions for sensitive products, while providing for much needed flexibility ...
Peters, Ralf, Vanzetti, David
core +1 more source
Sensitive rhyolitic pyroclastic deposits in the Tauranga region: mineralogy, geomechanics and microstructure of peak and remoulded states [PDF]
, 2012 Soil sensitivity has previously been recognised as a significant contributor to soil failures both internationally and within New Zealand, particularly in the Tauranga region.
Cunningham, Michael J.
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source