Results 141 to 150 of about 8,396,703 (346)

The addition of FAIMS increases targeted proteomics sensitivity from FFPE tumor biopsies [PDF]

, 2022
Steve M. M. Sweet, David Chain, Wen Yu, Philip Martin, Marlon C. Rebelatto, Andrew G. Chambers, Fabiola Cecchi, Yeoun Jin Kim   +7 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Efficient Cataluminescence Sensor for Detecting Methanol Based on NiCo₂O₄//MIL-Ti₁₂₅ Polyhedral Composite Nano-Materials

Chemosensors
Since methanol has a significant health hazard due to its inherent toxicity, it is urgent to develop a method capable of rapid, sensitive, and continuous monitoring of methanol.
Hongyan Wang, Ziyu Shao, Mao Cai, Guoji Shi, Bai Sun   +4 more
doaj   +1 more source

Quantifying the sensitivity and stability of the performance of a multi-purpose reservoir to model, inflow, and operational uncertainties

, 2023
Manvitha Molakala, Riddhi Singh
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Sensitive and Selective Electrochemical Detection of Hydrogen Peroxide Using a Silver-Incorporated CeO₂/Ag₂O Nanocomposite

Biosensors
Precision and real-time detection of hydrogen peroxide (H2O2) are essential in pharmaceutical, industrial, and defence sectors due to its strong oxidizing nature.
Gunasekaran Manibalan, Govindhasamy Murugadoss, Dharmalingam Krishnamoorthy, Venkataraman Dharuman, Shaik Gouse Peera   +4 more
doaj   +1 more source

Study Material for Manuscript: Sensitivity for Multimorbidity: The Role of Diagnostic Uncertainty of Physicians when Evaluating Multimorbid Video Case-based Vignettes v1 [PDF]

, 2018
Daniel Hausmann, Vera Kiesel, Lukas Zimmerli, Narcisa Schlatter, Amandine von Gunten, Nadine Wattinger, Thomas Rosemann   +6 more
openalex   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Design, Identification, and Sensitivity Analysis for Patient Preference Trials

, 2022
Dean Knox, Teppei Yamamoto, Matthew Baum, Adam J. Berinsky   +3 more
openalex   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source