Results 201 to 210 of about 8,396,703 (346)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Sleep Extension Improves Sleep Health but Not Insulin Sensitivity in People With Overweight or Obesity Who Maintain Habitual Short Sleep Schedules. [PDF]

Diabetes Care
Beals JW, Smith GI, Farabi SS, Patterson BW, Lucey BP, Broussard JL, Wright KP, Klein S.   +7 more
europepmc   +1 more source

Reviewer #3 (Public Review): Nonlinear sensitivity to acoustic context is a stable feature of neuronal responses to complex sounds in auditory cortex of awake mice

Marios Akritas, Alex G Armstrong, Jules M Lebert, Arne F Meyer, Maneesh Sahani, Jennifer F Linden   +5 more
openalex   +1 more source

Sensitivity of Trajectory Calculations to the Temporal Frequency of Wind Data [PDF]

, 1993
Kevin Doty, Donald J. Perkey
openalex   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Code Archive for 'What is the Observed Sensitivity of Arctic Sea Ice?'

Rauschenbach, Quentin
openalex   +1 more source

Oxygen Sensitivity of Reporter Genes: Implications for Preclinical Imaging of Tumor Hypoxia [PDF]

, 2007
Ivana Cecić, Denise A. Chan, Patrick D. Sutphin, Pritha Ray, Sanjiv S. Gambhir, Amato J. Giaccia, Edward E. Graves   +6 more
openalex   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Tree biomass sensitivity to ozone exposure

Viviano, Andrea, Hoshika, Yasutomo, Manzini, Jacopo, Baesso Moura, Barbara   +3 more
openalex   +1 more source

Patch-Clamp Study of Hepatitis C p7 Channels Reveals Genotype-Specific Sensitivity to Inhibitors [PDF]

, 2016
Ulrike Breitinger, Noha S. Farag, Nourhan K. M. Ali, Hans-Georg A. Breitinger   +3 more
openalex   +1 more source