Results 131 to 140 of about 29,659,346 (383)

The Future of Sensitivity Analysis: An essential discipline for systems modeling and policy support

Environmental Modelling & Software, 2020
S. Razavi, A. Jakeman, Andrea Saltelli, C. Prieur, B. Iooss, E. Borgonovo, E. Plischke, Samuele Lo Piano, T. Iwanaga, W. Becker, S. Tarantola, J. Guillaume, J. Jakeman, H. Gupta, N. Melillo, Giovanni Rabitti, V. Chabridon, Q. Duan, H. Maier   +18 more
semanticscholar   +1 more source

Incomplete Data in Clinical Studies: Analysis, Sensitivity, and Sensitivity Analysis [PDF]

Drug Information Journal, 2009
Statistical analysis often extends beyond the data available. This is especially true when data are incompletely recorded because ad hoc as well as model-based approaches are rooted not only in the observed data and the mechanism governing missingness, but also in the unobserved given the observed data.
openaire   +3 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Basics and Trends in Sensitivity Analysis

, 2021
S. Veiga, F. Gamboa, B. Iooss, C. Prieur
semanticscholar   +1 more source

D2PC sensitivity analysis [PDF]

, 1992
The Chemical Hazard Prediction Model (D2PC) developed by the US Army will play a critical role in the Chemical Stockpile Emergency Preparedness Program by predicting chemical agent transport and dispersion through the atmosphere after an accidental release. To aid in the analysis of the output calculated by D2PC, this sensitivity analysis was conducted
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Increased Sensitivity of Ethylenediamine Analysis for Norepinephrine [PDF]

, 1962
Herbert Sheppard, JOSEPH H. ZIMMERMAN
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Assessing the Sensitivity of Snow Depth Simulations to Land Surface Parameterizations within Noah-MP in Northern Xinjiang, China

Remote Sensing
Snow cover plays a crucial role in the surface energy balance and hydrology and serves as a key indicator of climate change. In this study, we conducted an ensemble simulation comprising 48 members generated by randomly combining the parameterizations of
Yuanhong You, Chunlin Huang, Yuhao Zhang
doaj   +1 more source

Experimental Sensitivity Data for Radioactivation Analysis with 14 MeV. Neutrons [PDF]

, 1963
Yuzuru KUSAKA, Haruo Tsuji, Takayoshi Adachi   +2 more
openalex   +1 more source