Results 131 to 140 of about 55,839,926 (326)
Tellus: Series A, Dynamic Meteorology and Oceanography, 2019 A low-order stochastically forced two-layer global energy balance model (EBM) admitting an analytical solution is developed for studying natural inter-annual, decadal and multi-decadal climate variability, and ultimately to better understand forced ...
Sergei Soldatenko, Robert Colman
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
EnergiesTo provide reliable safety margins in reactor design and safety analysis, the best estimate plus uncertainty (BEPU) analysis, which is recommended by the International Atomic Energy Agency (IAEA), has drawn increasing attention worldwide.
Haijun Liu +5 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Local Sensitivity and Diagnostic Tests [PDF]
In this paper we confront sensitivity analysis with diagnostic testing.Every model is misspecified, but a model is useful if the parameters of interest (the focus) are not sensitive to small perturbations in the underlying assumptions. The study of the e
Magnus, J.R., Vasnev, A.L.
core
Sensitivity analysis and uncertainty quantification of stiffness modulus using indirect tensile test
International Journal of Applied Mechanics and EngineeringThe stiffness modulus is a critical element in pavement engineering, as its accurate measurement directly reflects the load-bearing capacity of the pavement section.
Hicham Mezouara +4 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Using Dynamic Sensitivity Analysis to Assess Testability
, 1990 This paper discusses sensitivity analysis and its relationship to random black box testing. Sensitivity analysis estimates the impact that a programming fault at a particular location would have on the program's input/output behavior.
Voas, Jeffrey +2 more
core
Automated Sensitivity Analysis in Early Space Mission Design [PDF]
, 2012 Concurrent Engineering in space mission design features several hundred design parameters provided by more than a dozen domain experts. The quality of the design strongly depends on the individual expertise of the people in the team, their experience and
Schaus, Volker +3 more
core