Results 181 to 190 of about 55,839,926 (326)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Regional Variance-Based Sensitivity Analysis and a Study of Regional Equifinality. [PDF]
Risk AnalHelo J, Kozlova M, Roy P, Yeomans JS.
europepmc +1 more source
SENSITIVITY ANALYSIS IN FACTOR ANALYSIS REGRESSION
Journal of the Japanese Society of Computational Statistics, 1993 Mateo, Zenaida F. +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Assessing spatial uncertainties of land allocation using the scenario approach and sensitivity analysis [PDF]
The paper assess uncertainty of future spatial allocation of agricultural land in Europe. To assess the possible future development of agricultural production and land for the period 2000 – 2030, two contrasting scenarios are constructed.
Tabeau, Andrzej A. +2 more
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Modeling and Sensitivity Analysis of GaN HEMT Biosensor. [PDF]
Biosensors (Basel)Yesayan A, Sallese JM.
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
The Journey of Cornfield's Inequalities and How They Shaped Modern Sensitivity Analysis. [PDF]
Obs StudLun Z.
europepmc +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
, 2006 This paper deals with two kinds of optimisation problems, relevant to the optimised source distribution and the shape optimum design, using Continuum Design Sensitivity Analysis (CDSA) in combination with standard electromagnetic (EM) software.
Lowther, D.A. +6 more
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