Results 241 to 250 of about 2,573,895 (298)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

An Internal Validation Assessment of Scale Across Composite Index Model Structures. [PDF]

Risk Anal
Hinojos S, Grady C.
europepmc   +1 more source

Comparison of methods to handle missing values in a binary index test in a diagnostic accuracy study - a simulation study. [PDF]

BMC Med Res Methodol
Juljugin D, Stahlmann K, Zapf A.
europepmc   +1 more source

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A New Dynamic Index of Insulin Sensitivity

IEEE Transactions on Biomedical Engineering, 2006
Insulin sensitivity is a crucial parameter of glucose metabolism. The standard measures of insulin sensitivity obtained by an euglycaemic hyperinsulinaemic clamp, Si(clamp), or by the minimal model (MM), SI, do not account for the dynamics of insulin action, i.e., how fast or slow insulin action reaches its plateau value.
PILLONETTO, GIANLUIGI, A. CAUMO, SPARACINO, GIOVANNI, COBELLI, CLAUDIO   +3 more
openaire   +3 more sources

Cortisol as a sensitive index of heat-intolerance

Physiology & Behavior, 1982
The relationship between plasma cortisol levels, core temperatures, heat storage and the appearance of subjective manifestations of heat intolerance were investigated in two groups of 4 and 3 men, respectively. The first group underwent 4 randomized experimental sessions: a control session and three heat-exposure sessions (A: 48 degrees C, 34 Torr, 80 ...
M, Follenius, G, Brandenberger, S, Oyono, V, Candas   +3 more
openaire   +2 more sources

The Parent Sensitivity to Child Anxiety Index

Child Psychiatry & Human Development, 2018
Anxiety sensitivity (AS) is the perception that anxiety symptoms and experiences have negative consequences, and has been identified as a risk factor for the development of anxiety disorders. AS has been measured in adults and in children, but to date, the construct of parent's sensitivity to their children's anxiety symptoms has not been identified ...
Karl, Wissemann, Julia Y, Gorday, Alexandria, Meyer   +2 more
openaire   +2 more sources