Results 81 to 90 of about 715,092 (262)

Predictability Limit of the 2021 Pacific Northwest Heatwave From Deep‐Learning Sensitivity Analysis

Geophysical Research Letters
The traditional method for estimating weather forecast sensitivity to initial conditions uses adjoint models, which are limited to short lead times due to linearization around a control forecast.
P. Trent Vonich, Gregory J. Hakim
doaj   +1 more source

Input Sensitivity and Simulation Accuracy of WindNinja Wind Field Simulations in Complex Plateau Mountainous Terrain

Fire
Near-surface wind field simulation in complex mountainous terrain is essential for predicting wildfire behavior and supporting fire risk management. WindNinja, a widely used diagnostic wind downscaling model, is strongly dependent on its initial input ...
Xiaoxiao Li, Kaida Yan, Shiyuan Zhang, Liqing Si, Lifu Shu, Mingyu Wang, Weike Li, Fengjun Zhao, Qiuhua Wang   +8 more
doaj   +1 more source

Further investigation on adjoint sensitivity of surface precipitation to initial conditions

Meteorologische Zeitschrift, 2007
The adjoint version of the Canadian global numerical weather prediction model including moist physical parameterizations is used to investigate the sensitivity of surface precipitation to initial conditions.
Jean-François Mahfouf, Bernard Bilodeau
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Model of sensitivity to the initial conditions of the equations of motion in the electric fieldn

Computational Problems of Electrical Engineering
A numerical method for calculating ste¬ady periodic processes of nonlinear differential equations of motion in an electric field is proposed based on their integration under initial conditions that exclude transi¬ent reaction. The calculation of such initial conditions is based on Newton's iterative formula.
openaire   +3 more sources

Improved numerical solutions for chaotic-cancer-model

AIP Advances, 2017
In biological sciences, dynamical system of cancer model is well known due to its sensitivity and chaoticity. Present work provides detailed computational study of cancer model by counterbalancing its ...
Muhammad Yasir, Salman Ahmad, Faizan Ahmed, Muhammad Aqeel, Muhammad Zubair Akbar   +4 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source