Results 321 to 330 of about 735,970 (407)

Prediction of Respiratory Irritation and Respiratory Sensitization of Chemicals Using Structural Alerts and Machine Learning Modeling. [PDF]

Toxics
Chushak Y, Keebaugh A, Clewell RA.
europepmc   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatment. [PDF]

Front Pain Res (Lausanne)
Souissi A, Prieto-González P, Ben Saad H.   +2 more
europepmc   +1 more source

H3K36me3‐Guided m6A Modification of Oncogenic L1CAM‐AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma

Advanced Science, EarlyView.
L1CAM‐AS1 is identified as a novel H3K36me3‐guided, m6A‐modified long noncoding RNA (lncRNA) in hepatocellular carcinoma (HCC) cells. L1CAM‐AS1 stabilizes RAN protein, enhances M2 macrophages‐released CCL5‐induced nuclear import of RELA, activates the NF‐κB signaling, up‐regulates CCL2 expression and secretion from HCC cells, and enhances M2 ...
Teng Wang, Linyu Han, Yanfei Huo, Long Zhang, Yizhou Huang, Nasha Zhang, Ming Yang   +6 more
wiley   +1 more source

Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment. [PDF]

Lung
Birring SS, Dicpinigaitis PV, Maher TM, Mazzone SB, Page CP, Hawi A, Sciascia T, Morice AH.   +7 more
europepmc   +1 more source

The Non‐Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF‐β‐E2F1 Axis

Advanced Science, EarlyView.
Intrahepatic microenvironment greatly impacts duration and degree of HSCs activation and development of liver fibrosis. By inhibiting TGFβ‐E2F1‐driven production of profibrogenic factors (CTGF and THBS1), hepatocyte ChREBPα monitors hepatic microenvironment and suppresses the overactivation of HSCs.
Jian Zhang, Yuee Zhao, Gauthami Pulivendala, Qing Zhang, Liangyou Rui, Jiashi Gao, Huiwen Wang, Gary Zhang, Alli Nuotio‐Antar, Xin Tong, Lei Yin   +10 more
wiley   +1 more source

Nociplastic pain: exploring the concept and ongoing discussions. [PDF]

Korean J Pain
Quintner J, Weisman A, Cohen M.
europepmc   +1 more source

Pressure‐Induced Ultralow Critical Micelle Concentration of Surfactant for Encapsulating Dye

Advanced Science, EarlyView.
Ultralow critical micelle concentration (CMC) is successfully achieved by pressure. Compared to 917.2 ± 8.7 µm for cetyl trimethyl ammonium bromide at 0.10 MPa, the ultralow CMC at 0.80 GPa is a ≈111‐fold reduction for 8.3 ± 0.1 µm. The detection of ultralow CMC under pressure is owed to the pressure‐induced fluorescence quenching of the coumarin 35 ...
Qi Li, Xinze Liu, Peng Zhu, Meilin Guo, Guangxiong Hu, Jianbo Gao, Cailong Liu, Ying Shi   +7 more
wiley   +1 more source

Implementation of early warning, alert and response: An experience from the Marburg virus disease outbreak response in Kagera, Tanzania, March to May 2023. [PDF]

PLoS One
Musyani A, Mwakapasa E, Mponela M, Ngailo L, Rabiel I, Khama M, Mmbaga E, Sindato C, Noah M, Solomon W, Mrema G, Ngenzi D, Kauki G, Manasseh G, Mahande M, Sarakikya E, Mauka W, Machumi L, Mcharo J, Mtalika M, Kanyankore C, Mukurasi K, Beyanga M, Horumpende P, Kiremeji M, Kinyenje E, Mnkeni E, Yango M, Kundy FM, Leonard S, Mwanahapa P, Mutayoba R, Mayige M, Gatei W, Mmbaga V, Magembe G.   +35 more
europepmc   +1 more source