Results 101 to 110 of about 208,446 (298)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

High output power low temperature polysilicon thin-film transistor boost converters for large-area sensor and actuator applications

npj Flexible Electronics
Large-area electronic sensor and actuator arrays are suitable systems for thin-film transistor (TFT) technology with numerous applications from consumer electronics to healthcare. Considerable effort is being spent to make these arrays a reality. However,
Mauricio Velazquez Lopez, Nikolas Papadopoulos, Paoline Coulson, Bjorn Vandecasteele, Kris Myny   +4 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Antenna-coupled TES bolometers used in BICEP2, Keck array, and SPIDER

, 2015
We have developed antenna-coupled transition-edge sensor (TES) bolometers for a wide range of cosmic microwave background (CMB) polarimetry experiments, including BICEP2, Keck Array, and the balloon borne SPIDER. These detectors have reached maturity and
A. D. Turner, A. G. Vieregg, A. Orlando, A. S. Rahlin, A. Trangsrud, A. Weber, B. G. Keating, C. A. Bischoff, C. B. Netterfield, C. D. Dowell, C. D. Reintsema, C. D. Sheehy, C. L. Kuo, C. L. Wong, C. Pryke, D. Barkats, D. V. Wiebe, E. Bullock, E. M. Leitch, G. C. Hilton, G. Chattopadhyay, G. Davis, G. P. Teply, H. G. LeDuc, H. Hui, H. T. Nguyen, I. Buder, J. A. Bonetti, J. A. Brevik, J. E. Tolan, J. J. Bock, J. M. Kovac, J. P. Filippini, J. P. Kaufman, J. Zmuidzinas, K. D. Irwin, K. Megerian, K. S. Karkare, K. W. Yoon, L. Duband, L. Moncelsi, M. Amiri, M. C. Runyan, M. Halpern, M. Hasselfield, M. Lueker, N. Llombart, null null, P. A. R. Ade, P. K. Day, P. Mason, P. Wilson, R. O’Brient, R. S. Tucker, R. Schwarz, R. V. Sudiwala, R. W. Aikin, R. W. Ogburn IV, S. A. Kernasovskiy, S. Fliescher, S. J. Benton, S. Kefeli, S. R. Golwala, S. R. Hildebrandt, S. Richter, V. Hristov, W. C. Jones, Z. K. Staniszewski   +67 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Advances in the application of sensor arrays based on nanozymes

Biosensors and Bioelectronics: X
As efficient biocatalysts, enzymes can catalyze various reactions under mild conditions, and have excellent substrate specificity and selectivity. However, the high cost of preparation and difficulty in recovery of natural enzymes have seriously hindered
Ying Ma, Heng Liu, Bin Li, Na Lu
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Two-Dimensional Direction of Arrival Estimation for Improved Archimedean Spiral Array With MUSIC Algorithm

IEEE Access, 2018
Direction-of-Arrival (DOA) estimation capability of sensor arrays is greatly influenced by geometric configuration of arrays. We proposed a new type 2-D planar array, improved Archimedean spiral array (IASA), to arrange sensor elements and enhance the ...
Jin Chen, Sheng Guan, Ying Tong, Lei Yan
doaj   +1 more source

Sparse Sensing with Semi-Coprime Arrays

, 2018
A semi-coprime array (SCA) interleaves two undersampled uniform linear arrays (ULAs) and a $Q$ element standard ULA. The undersampling factors of the first two arrays are $QM$ and $QN$ respectively where $M$ and $N$ are coprime. The resulting non-uniform
Adhikari, Kaushallya
core   +1 more source

Pillar-array based optical sensor

Optics Express, 2010
An optical microcavity based on pillar arrays has been fabricated in Si/SiO(2) material system. Transmission measurement was taken and a quality factor as high as 27,600 was observed. This cavity was tested for sensing applications by immersing into optical fluids with accurate refractive indices.
Tao, Xu, Ning, Zhu, Michelle Y-C, Xu, Lech, Wosinski, J Stewart, Aitchison, H E, Ruda   +5 more
openaire   +2 more sources