Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley +1 more source
Augmented pain-evoked primary sensorimotor cortex activation in adolescent girls with juvenile fibromyalgia. [PDF]
Tong H +9 more
europepmc +1 more source
Background Accurate temporal prediction, essential for adaptive motor behavior, relies on corticobasal ganglia circuits. In Parkinson's disease (PD), both motor and non‐motor functions are impaired. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) effectively alleviates motor symptoms, but its effects on non‐motor domains, like temporal ...
Rebecca Burke +5 more
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Somatotopic disruption of the functional connectivity of the primary sensorimotor cortex in complex regional pain syndrome type 1. [PDF]
Hotta J +5 more
europepmc +1 more source
(1) To sample subjective patient rating using the Visual Analogue Scale (VAS), random stimulation parameters were presented to the study subjects. (2) Next, corresponding volumes of tissue activated (VTA) were generated and paired with VAS values.
Sophia Peschke +9 more
wiley +1 more source
Sensorimotor cortex activity during basketball dribbling and its relation to creativity. [PDF]
Kanatschnig T +4 more
europepmc +1 more source
Light-based mapping of mouse sensorimotor cortex
The motor cortex controls voluntary, skilled movements. It possesses a basic somatotopic organization, but its fine structure remains controversial. Although the reorganization of motor cortex after brain injury is believed to be a critical part of behavioral recovery, our understanding of this process has been constrained by technical limitations ...
openaire +1 more source
Aberrant Beta‐Band Network Alteration Preceding Freezing of Gait in Parkinson's Disease
Abstract Background Freezing of gait (FOG) is a debilitating motor symptom observed in the advanced stages of Parkinson's disease (PD), characterized by an abrupt inability to initiate or continue forward walking. Whole‐brain functional connectivity analysis has shown promise in elucidating the underlying pathophysiology and identifying potential ...
Yanqiu Tian +3 more
wiley +1 more source
Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping. [PDF]
Grier HA, Salimian S, Kaufman MT.
europepmc +1 more source
Single-pulse TMS functional mapping of sensorimotor cortex during decision-making task. [PDF]
Udoratina A +7 more
europepmc +1 more source

