Results 211 to 220 of about 74,884 (346)

Guidelines for Diagnosis of Noise‐Induced Hearing Loss and Their Specificity

open access: yesClinical Otolaryngology, EarlyView.
ABSTRACT Objectives A recent paper by Moore, Lowe and Cox has proposed guidelines for diagnosing noise‐induced hearing loss (NIHL). It is referred to here as the MLC guidelines. Our aim was to assess the specificity of those guidelines (i.e., freedom from false‐positive outcomes) and compare with pre‐existing guidelines.
Mark E. Lutman   +2 more
wiley   +1 more source

Systematic Review and Meta‐Analysis of Audiometric Parameters for Assistive Hearing Technology for Adults and Children With Tympanic Membrane Perforation

open access: yesClinical Otolaryngology, EarlyView.
ABSTRACT Introduction Tympanic membrane perforation can cause hearing impairment with detrimental effects on communication and quality of life, and is a problem affecting an estimated 250 million people. To date, there is little analysis to inform public policy on options for assistive hearing technology rehabilitation in this group.
Thomas Hampton   +3 more
wiley   +1 more source

Direct reprogramming of fibroblasts into spiral ganglion neurons by defined transcription factors

open access: yesCell Proliferation, EarlyView.
A combination of Ascl1, Pou4f1 and Myt1l was identified to promote functional reprogramming of cochlear spiral ganglion neurons based on biochemical, electrophysiological and single‐cell transcriptomic analyses. Abstract Degeneration of the cochlear spiral ganglion neurons (SGNs) is one of the major causes of sensorineural hearing loss and ...
Yuhang Huang   +11 more
wiley   +1 more source

Conditional Overexpression of Net1 Enhances the Trans‐Differentiation of Lgr5+ Progenitors into Hair Cells in the Neonatal Mouse Cochlea

open access: yesCell Proliferation, EarlyView.
This work investigated the in vivo role of Net1 in cochlear hair cell (HC) regeneration. Conditional overexpression of Net1 in Lgr5+ progenitors of neonatal mouse cochlea enhance HC regeneration by inducing direct trans‐differentiation of Lgr5+ progenitors into HCs probably via activation of Atoh1, Gfi1, and Pou4f3 transcription factors.
Yanqin Lin   +10 more
wiley   +1 more source

Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells

open access: yesCell Proliferation, EarlyView.
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai   +9 more
wiley   +1 more source

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