Results 211 to 220 of about 54,480 (306)

Understanding the Role of Genetic Testing in Diagnosing a Complex Pediatric Case

open access: yesClinical Case Reports, Volume 14, Issue 6, June 2026.
Visualization of ZPR1 protein variants. ABSTRACT We report the case of a 13‐month‐old female with multiple congenital anomalies including microcephaly, generalized hypotonia, sensorineural hearing loss, visual impairment, alopecia, and hypoplastic kidneys with chronic kidney disease, and dysmorphic craniofacial features.
Giavanna Verdi   +6 more
wiley   +1 more source

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1522-1536, June 2026.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra   +4 more
wiley   +1 more source

Magnitude, Patterns and Factors Associated With Sensorineural Hearing Loss Among Hypertensive Adults at a Tertiary Hospital in Northern Tanzania

open access: yesEye &ENT Research, Volume 3, Issue 2, Page 101-106, June 2026.
ABSTRACT Background Hearing loss affects 1.5 billion people globally, with sensorineural hearing loss (SNHL) linked to hypertension. Hypertension affects 1.39 billion people worldwide and its prevalence is rising sharply in Sub‐Saharan Africa. While 12% of Tanzanian population has cardiovascular diseases, including hypertension and recent studies ...
Johnson Shayo   +3 more
wiley   +1 more source

Sudden sensorineural hearing loss

open access: yesCanadian Medical Association Journal
Newsted, Daniel   +2 more
openaire   +2 more sources

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