Results 81 to 90 of about 42,755 (252)

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Are systemic oral steroids effective for sensorineural hearing loss in bullous myringitis? Considerations from a preliminary study

B-ENT, 2011
Are systemic oral steroids effective for sensorineural hearing loss in bullous myringitis? Considerations from a preliminary study. Background: It is common in clinical practice to administer systemic steroids to treat sensorineural hearing loss due to ...
A. Ciorba, R. Bovo, M. Rosignoli, A. Martini   +3 more
doaj   +2 more sources

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Triggered Calcium Lightning Programs Cochlear Development

Exploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma, Hai‐Peng Wang, Yu‐Meng Jiang, Ke Lai, Ming‐Xian Li, Zhen Zhang, Li‐Na Gong, Jing‐Wei Lai, Kai‐Ming Su, Lu‐Yang Wang, Hui Wang, Shan‐Kai Yin, Hao He, Hai‐Bo Shi   +13 more
wiley   +1 more source

Acute kidney injury, secondary to valacyclovir use during pregnancy for the prevention of fetal cytomegalovirus infection

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract High dose valacyclovir treatment of pregnant women has become a common treatment for primary CMV infection, to prevent vertical transmission to the fetus. We present a case of a healthy young pregnant female with primary CMV infection during the first trimester who was diagnosed with acute kidney injury secondary to valacyclovir treatment ...
Jason Brafman, Yechiel Schlesinger, Moshe Barg, Shmuel Benenson   +3 more
wiley   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Clinical progress note: Mumps

Journal of Hospital Medicine, EarlyView.
Abstract Mumps was a common childhood viral illness before the implementation of the measles, mumps, and rubella (MMR) vaccination in 1967. There was a significant decrease in mumps cases in the postvaccine era; however, there has been an increase in outbreaks in the United States over the past two decades.
Sarah Ludvigsen, Mati Segev
wiley   +1 more source

Predicting cochlear structural alterations from auditory function in age‐related hearing loss mice based on optical coherence tomography

Journal of Intelligent Medicine, EarlyView.
Abstract With global population aging, age‐related hearing loss has become a major public health concern. Understanding the relationship between auditory functional decline and cochlear structural degeneration is essential for early detection and precise intervention.
Shu Zheng, Zhiqi Li, Junyue Wang, Guangjian Ni   +3 more
wiley   +1 more source

SENSORINEURAL HEARING LOSS

Sensorineural hearing loss is a complex and multifactorial condition characterized by permanent reduction in auditory function due to damage to the inner ear structures or auditory nerve. This disorder affects both children and adults, significantly impairing communication, social interaction, and language development.
Quan Lu, Anita Jeyakumar
  +5 more sources

Multi‐Frequency Electrocochleography Results in Fewer Drop Alarms During Cochlear Implant Insertion

The Laryngoscope, EarlyView.
A novel multi‐frequency electrocochleography (ECochG) algorithm used during cochlear implant electrode insertion is associated with fewer drop alarms and an increase in optimal insertion track patterns. Multi‐frequency ECochG may provide a more accurate assessment of the cochlear microenvironment when compared to single‐frequency ECochG.
Mana Espahbodi, Ali Syed, Alex Tu, Michael D. Seidman, Christopher J. Danner, Kyle P. Allen, Loren J. Bartels, Syed F. Ahsan, Courtney C.J. Voelker, Nicholas L. Deep, Jacob B. Hunter, Rebecca C. Chiffer, Elias M. Michaelides, Mohamed Elrakhawy, Matthew W. Miller, Harrison W. Lin, Hamid R. Djalilian, Esther X. Vivas, Simon I. Angeli, Michael Hoa, H. Jeffrey Kim, Mark H. Widick, Katrina R. Stidham, Neil S. Patel, Richard K. Gurgel, Karl W. Doerfer, Kanthaiah Koka, Michael S. Harris   +27 more
wiley   +1 more source