Results 191 to 200 of about 190,244 (278)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

High Sensory Processing Sensitivity and Sexual Functioning

, 2018
This dissertation is part of the second year of the second cycle of studies in Clinical and Health Psychology. The document is then constituted by a first part that corresponds to a scientific article, subdivided into four parts - introduction, procedure, results and discussion ; and a second part that includes a theoretical annex relating to the ...
openaire   +1 more source

Painfully Sensitive: How Sensory Processing Sensitivity Affects Healthy Adolescents' Perception of Pain. [PDF]

J Pain Res
Hochreuter J, Wehrli S, Locher C, Lionetti F, Kossowsky J, Pluess M, Koechlin H.   +6 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Maternal adjustment in expatriate and non-expatriate contexts: examining the role of sensory processing sensitivity and perceived social support. [PDF]

Front Psychol
Lagarrigue KK, Sadurní Brugué M, Acevedo BP, Betancort M.   +3 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Demographic profile of Sensory Processing Sensitivity

Personality and Individual Differences
María Luz Morales-Botello, Moisés Betancort, Manuela Pérez-Chacón, Rosa-María Rodríguez-Jiménez, Antonio Chacón   +4 more
openaire   +1 more source

Psychological factors associated with sensory processing sensitivity in caregiving contexts: A protocol for a systematic review and meta-analysis. [PDF]

PLoS One
Connery T, Doyle M, Murphy M, Setti A.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Sensory Processing Sensitivity in Childhood – A Systematic Mapping Review

This project presents a systematic mapping review of Sensory Processing Sensitivity (SPS) in ...
Alessandra Sperati, Alexandra Burger
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