Results 121 to 130 of about 2,260,039 (328)

Does the motor system need intermittent control? [PDF]

, 2014
Explanation of motor control is dominated by continuous neurophysiological pathways (e.g. trans-cortical, spinal) and the continuous control paradigm.
Brembs, Cisek, Cohen, Cornelis van de Kamp, Diedrichsen, Dux, Frank, Gawthrop, Gawthrop, Gawthrop, Gawthrop, Gollee, Haber, Hardwick, Henrik Gollee, Houk, Ian David Loram, Kleinman, Lakie, Levison, Loram, Loram, Loram, Loram, Loram, Loram, Marsden, Martin Lakie, Peter J. Gawthrop, Pruszynski, Redgrave, Redgrave, Ronco, Todorov, Van De Kamp, Van de Kamp, Vince, Yin   +37 more
core   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The persistence of a visual dominance effect in a telemanipulator task: A comparison between visual and electrotactile feedback [PDF]

, 1981
The possibility to use an electrotactile stimulation in teleoperation and to observe the interpretation of such information as a feedback to the operator was investigated. It is proposed that visual feedback is more informative than an electrotactile one;
Gaillard, J. P.
core   +1 more source

Learning Sensor Feedback Models from Demonstrations via Phase-Modulated Neural Networks

, 2018
In order to robustly execute a task under environmental uncertainty, a robot needs to be able to reactively adapt to changes arising in its environment. The environment changes are usually reflected in deviation from expected sensory traces.
Meier, Franziska, Schaal, Stefan, Su, Zhe, Sutanto, Giovanni   +3 more
core   +1 more source

Comparison of linear frequency and amplitude modulation for intraneural sensory feedback in bidirectional hand prostheses

Scientific Reports, 2018
Recent studies have shown that direct nerve stimulation can be used to provide sensory feedback to hand amputees. The intensity of the elicited sensations can be modulated using the amplitude or frequency of the injected stimuli. However, a comprehensive
G. Valle, F. Petrini, I. Strauss, F. Iberite, E. D’Anna, G. Granata, M. Controzzi, C. Cipriani, T. Stieglitz, P. Rossini, A. Mazzoni, S. Raspopovic, S. Micera   +12 more
semanticscholar   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Rapid Integration of Artificial Sensory Feedback during Operant Conditioning of Motor Cortex Neurons

Neuron, 2017
Summary Neuronal motor commands, whether generating real or neuroprosthetic movements, are shaped by ongoing sensory feedback from the displacement being produced.
Mario Prsa, G. L. Galiñanes, D. Huber
semanticscholar   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Circuit Dysfunction in SOD1-ALS Model First Detected in Sensory Feedback Prior to Motor Neuron Degeneration Is Alleviated by BMP Signaling

Journal of Neuroscience, 2018
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease for which the origin and underlying cellular defects are not fully understood.
A. Held, P. Major, Asli Sahin, R. Reenan, D. Lipscombe, K. Wharton   +5 more
semanticscholar   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source