Results 61 to 70 of about 148,681 (258)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Patterns of sensory integration dysfunction in children with confirmed learning differences attending a short-term remedial school in Kwa-Zulu-Natal

South African Journal of Occupational Therapy
Introduction: The link between sensory integration (SI) dysfunction and learning differences is well-established, highlighting its influence on academic abilities.
Nicola van Ravenswaay, Gina Rencken, Pragashnie Govender   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Visuomotor expertise in volleyball: saccadic latency and absolute alpha power

Frontiers in Psychology
This study investigated differences in saccadic latency and absolute alpha power during eye movement preparation between young volleyball athletes and non-athletes.
Renan Vicente, Renan Vicente, Juliana Bittencourt, Renato Fonseca, Renato Fonseca, Giovanna Zanchetta, Giovanna Zanchetta, Alexandre Vasconcelos, Carlos Amoroso, Carlos Amoroso, Marcos Machado, Marcos Machado, Elida Costa, Isabelle Fernandes, Isabelle Fernandes, Victor Marinho, Jesse Di Giacomo, Jesse Di Giacomo, Eduardo Nicoliche, Danielle Aprigio, Marcelo Nobre, Marcelo Nobre, Marco Orsini, Victor Hugo Bastos, Silmar Teixeira, Antonio E. Nardi, Mauricio Cagy, Bruna Velasques, Bruna Velasques, Pedro Ribeiro, Pedro Ribeiro, Henning Budde   +31 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Sensory Integration and Creative Imagination in Shaping Artistic Expression among the Blind: Ashraf Armagan as a Model

الاكاديمي
The present study aimed to investigate the role of sensory integration and creative imagination in shaping artistic expression among blind individuals, using a descriptive analytical approach.
Merfat Mohammed Mahdi Bassi
doaj   +1 more source