Results 51 to 60 of about 338,560 (308)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Prevalence of dual sensory impairment in veterans: a rapid systematic review

Frontiers in Rehabilitation Sciences
Dual sensory impairment (DSI) is prevalent in the older population, but due to exposure to military-related risk factors, it is a particular problem for veterans, older and younger.
Zara Raza, Zara Raza, Syeda F. Hussain, Renata S. M. Gomes, Renata S. M. Gomes   +4 more
doaj   +1 more source

Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons. [PDF]

PLoS ONE, 2012
Sensory organs are constantly exposed to physical and chemical stresses that collectively threaten the survival of sensory neurons. Failure to protect stressed neurons leads to age-related loss of neurons and sensory dysfunction in organs in which the ...
Young-Mi Lim, Shigeo Hayashi, Leo Tsuda
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Physical, psychosocial and dual-career loads as risk factors for injuries and illnesses in elite handball players: a 45-week prospective cohort study

Frontiers in Sports and Active Living
IntroductionWhile training and competition load are well-documented risk factors for injury, the influence of dual-career loads, life stressors and overall load on both injury and illness remain less clear.
Kristina Drole, Armin Paravlic, Armin Paravlic, Kathrin Steffen, Kathrin Steffen, Mojca Doupona   +5 more
doaj   +1 more source

Prevalence and clinical implications of nerve injury during bone patellar tendon bone harvesting for anterior cruciate ligament reconstruction

Journal of Orthopaedic Surgery, 2017
Purpose: Tendon harvesting for anterior cruciate ligament (ACL) reconstruction often injure sensory branches of the saphenous nerve (SN). Our purpose was to estimate the prevalence and postoperative course of sensory nerve injuries in bone patellar ...
Barak Haviv, Mustafa Yassin, Ehud Rath, Shlomo Bronak   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The benefits of sensation on the experience of a hand: A qualitative case series.

PLoS ONE, 2019
BackgroundThe experience of upper limb loss involves loss of both functional capabilities and the sensory connection of a hand. Research studies to restore sensation to persons with upper limb loss with neural interfaces typically measure outcomes ...
Emily L Graczyk, Anisha Gill, Dustin J Tyler, Linda J Resnik   +3 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Associations between subjective and objective measures of stress and load: an insight from 45-week prospective study in 189 elite athletes

Frontiers in Psychology
IntroductionThe aim of this study was to investigate the associations between subjective and objective measures of stress and load in elite male handball players at both the group and individual levels.MethodsIn this 45-week prospective cohort study, 189
Kristina Drole, Mojca Doupona, Kathrin Steffen, Kathrin Steffen, Aleš Jerin, Aleš Jerin, Armin Paravlic, Armin Paravlic   +7 more
doaj   +1 more source