Results 101 to 110 of about 125,461 (242)

High Sensitivity to Interpersonal Interaction: Development of a Measurement

Psychologica Belgica
Interpersonal sensitivity is an aspect of Sensory Processing Sensitivity (SPS) that has been unexplored precisely despite potentially playing an even more significant role in individuals with SPS.
Karina Salud Montoya-Pérez, Ferran Padrós-Blázquez, Rocío Montoya-Pérez   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Painfully Sensitive: How Sensory Processing Sensitivity Affects Healthy Adolescents’ Perception of Pain

Journal of Pain Research
Jana Hochreuter,1– 3 Susanne Wehrli,1– 4 Cosima Locher,5,6 Francesca Lionetti,7 Joe Kossowsky,8,9 Michael Pluess,10,11 Helen Koechlin1– 3 1Department of Psychosomatics and Psychiatry, University Children’s Hospital, University of Zurich, Zurich ...
Hochreuter J, Wehrli S, Locher C, Lionetti F, Kossowsky J, Pluess M, Koechlin H   +6 more
doaj  

The Relationship between Sensory Processing Sensitivity and Substance Craving with the Mediating Role of Resilience in Addicted Prisoners [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk
Introduction: High sensory processing sensitivity in the face of psychological pressures predisposes individuals to substance craving, while resilience, as a protective factor, plays a role in reducing this vulnerability.
Hassan Shafiei, Alireza Khaki
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Sensory Processing Sensitivity : En valideringsstudie

, 2019
Sensory processing sensitivity is believed to be a personality trait in up to 20% of individuals, including other species than humans. The trait is associated with higher levels of unpleasant arousal, a higher sensitivity to sensory input, empathy and a deeper level of informational processing in the brain.
openaire   +1 more source