Results 211 to 220 of about 129,089 (307)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Sensory processing sensitivity, anxiety, and short-term heart rate variability in older adults living at high southern latitudes: a brief report. [PDF]

Front Psychiatry
Baeza D, Huirimilla-Casanova L, Estrada C, Buccella S, Castillo-Aguilar M, Núñez-Espinosa C.   +5 more
europepmc   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Painfully Sensitive: How Sensory Processing Sensitivity Affects Healthy Adolescents' Perception of Pain. [PDF]

J Pain Res
Hochreuter J, Wehrli S, Locher C, Lionetti F, Kossowsky J, Pluess M, Koechlin H.   +6 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Maternal adjustment in expatriate and non-expatriate contexts: examining the role of sensory processing sensitivity and perceived social support. [PDF]

Front Psychol
Lagarrigue KK, Sadurní Brugué M, Acevedo BP, Betancort M.   +3 more
europepmc   +1 more source

Sensory Processing Sensitivity in Childhood – A Systematic Mapping Review

This project presents a systematic mapping review of Sensory Processing Sensitivity (SPS) in ...
Alessandra Sperati, Alexandra Burger
core  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Psychological factors associated with sensory processing sensitivity in caregiving contexts: A protocol for a systematic review and meta-analysis. [PDF]

PLoS One
Connery T, Doyle M, Murphy M, Setti A.
europepmc   +1 more source