Results 121 to 130 of about 890,725 (290)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Multi-way models for sensory profiling data
, 2007 One of the problems in analyzing sensory profiling data is to handle the systematic individual differences in the assessments from different panelists. It is unavoidable that different persons have, at least to a certain degree, different perceptions of ...
Kiers, Henk A.L. +8 more
core +1 more source
Integrating sensory analysis and voltammetry to explore oxidative susceptibility in red wines
Food Chemistry: XWine longevity is a key determinant of quality in premium wines, yet reliable tools to predict susceptibility to deterioration remain limited. This study evaluated longevity using two accelerated ageing models: controlled oxidation (COx) and anoxic ...
Mónica Bueno +9 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Validating rapid-sensory profiling methodologies and identifying strawberry flavours driving liking
, 2018 This thesis validated rapid-sensory profiling methodologies, to contribute to the growing body of evidence investigating these profiling techniques, and further understand their limitations and future potential applications.
Penelope Sarah Oliver (13795393)
core
, 2010 Dry-cured ham is one of the most representative typical meat products in Italy. Despite this, few works which describe its sensory profile through a holistic approach are available in the literature.
E. Pagliarini +3 more
core +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Chemical and Sensory Profiling of Monovarietal Extra Virgin Olive Oils from the Italian Marche Region. [PDF]
Antioxidants (Basel), 2020 Pacetti D +11 more
europepmc +1 more source