MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts
Advanced Science, EarlyView.We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang +5 more
wiley +1 more source
Evaluating the Utilities of Foundation Models in Single‐Cell Data Analysis
Advanced Science, EarlyView.This study delivers the first systematic, task‐level evaluation of single‐cell foundation models across eight core analytical tasks. By benchmarking 10 leading models with the scEval framework, it reveals where foundation models truly add value, where task‐specific methods still dominate, and provides concrete, reproducible guidelines to steer the next
Tianyu Liu +4 more
wiley +1 more source
Should Death Be So Different?: Sentencing Purposes and Capital Jury Decisions in an Era of Smart on Crime Sentencing Reform [PDF]
, 2017 We are in an era of “Smart on Crime” sentencing reform. Several states and the federal government have made major changes to their sentencing policies—from reducing the incarceration of low-level, nonviolent drug offenders to the use of evidence-based ...
Exum, Jelani Jefferson
core +3 more sources
Sentencing as craftwork and the binary epistemologies of the discretionary decision process [PDF]
, 2007 This article contends that it is time to take a critical look at a series of binary categories which have dominated the scholarly and reform epistemologies of the sentencing decision process.
Baumgartner +38 more
core +1 more source
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1
Advanced Science, EarlyView.Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang +10 more
wiley +1 more source
Illinois Government Research no. 56 1983: Prison Capacity and Sentencing Severity: A Look at Illinois, Michigan, and Pennsylvania [PDF]
, 1983 After a brief lull in the late seventies and early eighties, crime is once again a prime concern among a large number of Americans. More people are mentioning crime in periodic surveys of public problems than in the previous decade, and the 1982 ...
Nardulli, Peter F.
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Advanced Science, EarlyView.Microbial synthesis of nanomaterials (NMs) is eco‐friendly, but the screening of microorganisms is limited by inefficient traditional methods (currently only involving∽400 microorganisms/90 NMs). We propose AI framework MicrobeDiscover, integrating a knowledge graph of microbe‐NM interactions.
Ludi Wang +12 more
wiley +1 more source
Discontinuous Tradition of Sentencing Discretion: Koon\u27s Failure to Recognize the Reshaping of Judicial Discretion under the Guidelines, The [PDF]
, 1999 Can a judge exercise discretion and follow the law? Some think it impossible, seeing discretion as the opposite of law. Others have harmonized the two ideas, viewing discretion as the exercise of judgment according to and within the bounds of the law ...
Weinstein, Ian
core +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Alaska Sex Offense Law: What Has Changed [PDF]
, 2019 Alaska’s sex offense laws fall into three broad categories: crimes and defenses, sentencing, and post-release supervision and registry. This article discusses each in turn, looking at how these laws have changed following the 31st legislative session.The
Dunham, Barbara
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