Results 111 to 120 of about 29,868,759 (307)

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Spatial model of the Trooz Glacier dynamics based on meteorological data from the Akademik Vernadsky station

Український антарктичний журнал
This paper models the dynamics of the Trooz Glacier, Antarctic Peninsula. To integrate remote and meteorological data, we processed ice flow velocities derived from satellite radar imagery, air temperature, and precipitation obtained from the ERA5 ...
Kornyliy Tretyak, Denys Kukhtar
doaj   +1 more source

Leveraging Big Multitemporal Multisource Satellite Data and Artificial Intelligence for the Detection of Complex and Invisible Features: The Case of Extensive Irrigation Mapping

Archaeological Prospection, EarlyView.
ABSTRACT The detection of buried or obscured archaeological features remains a central challenge in landscape archaeology, particularly in the irrigated floodplains of Mesopotamia where levees and canals formed the basis of complex agrarian systems. This study presents a deep learning–based approach for the large‐scale, automated detection of ancient ...
Nazarij Buławka, Hector A. Orengo, Felipe Lumbreras Ruiz, Iban Berganzo‐Besga, Ekta Gupta   +4 more
wiley   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Improving flood channel detection in arid environments with Sentinel-1 InSAR coherence: a multi-sensor comparison from the April 2024 flood in Oman

Open Geosciences
In April 2024, northern Oman experienced an extreme flash flood triggered by rainfall totals exceeding one to two years of the regional average within 24 h.
Obrecht Laura, Löw Johannes, Plank Simon, Hadidi Ahmed, Sahwan Wahib, Ullmann Tobias   +5 more
doaj   +1 more source

Soil moisture estimation underneath crop cover using high incidence angle C-band Sentinel-1 SAR data

Kuwait Journal of Science
SAR's return signal sensitivity to dielectric constant and penetration through vegetation makes it ideal for large-scale soil moisture studies. High incidence angle SAR data is especially useful for understanding crop characteristics.
Hari Shanker Srivastava, Thota Sivasankar, Madhuri Dilip Gavali, Parul Patel   +3 more
doaj   +1 more source

“They say we're a rights‐respecting school but nobody knows what that really means”: Children's rights implementation in a Scottish secondary school

British Educational Research Journal, EarlyView.
Abstract Education has been an enduring feature of international human rights law since the Universal Declaration of Human Rights in 1948 and is the only human right that is compulsory for children. Appearing in all major human rights treaties, including the UN Convention on the Rights of the Child, education is multidimensional and a multiplier of ...
Amy Hanna
wiley   +1 more source

A Century of Learning: The Story of ESA's Education Committee, 1918–2025

The Bulletin of the Ecological Society of America, EarlyView.
Abstract The Education Committee and its precursors have been highly influential within the Ecological Society of America. Here we document the Education Committee's history, from its origins in reviewing curricular materials through major contributions to ecological literacy, teaching innovation, diversity initiatives, and professional development ...
Kenneth M. Klemow, Alan R. Berkowitz, Carmen R. Cid, Tom A. Langen, Margaret D. Lowman, George Middendorf, Julie A. Reynolds   +6 more
wiley   +1 more source

Isolating T‐Cell Potent Lentiviral Vector Subpopulations through Rational Design of Nanofiber Anion‐Exchange Adsorbents

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Generation of CAR‐T cell therapies relies predominantly on lentiviral vectors (LVs). As in vivo CAR‐T trials progress, demand for larger quantities of higher‐potency LV is expected. However, primary capture by anion‐exchange chromatography (AIEX) remains a major manufacturing bottleneck from use of adsorbents not tailored to LVs, leading to ...
George Pamenter, Gyorgy Ovari, Anurag Kulkarni, Thomas Williams‐Fegredo, Carol Knevelman, Kyriacos Mitrophanous, Lee Davies, Farzad Foroutan, Matthew Townsend, Stephen Goldrick, Daniel G. Bracewell   +10 more
wiley   +1 more source