Results 111 to 120 of about 113,448,228 (255)

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

The yield strikes back: Enhancing the transferability of field scale wheat and barley yield models by leveraging Sentinel-1/2

International Journal of Applied Earth Observations and Geoinformation
Accurate and transferable crop monitoring from remote sensing remains challenging because vegetation signals are strongly affected by phenological asynchrony, climatic variability, and sensor-specific responses.
Belen Franch, Italo Moletto-Lobos, Javier Tarín-Mestre, Lucio Mascolo, Eric Vermote, Natacha Kalecinski, Inbal Becker-Reshef, Alberto San-Bautista, Constanza Rubio, Sara San Francisco, Miguel Ángel Naranjo, Vanessa Paredes, David Nafria, Carlos Cantero-Martinez   +13 more
doaj   +1 more source

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor, Stefano Comai, Gianfranco Pasut, Franco Folli, Marco Gentilucci, Negar Gharavi, Sofia Raitsin, Thuy Van Nguyen, Marco Pappagallo, Andrea Mattarei, Paolo L. Manfredi, Sara De Martin   +11 more
wiley   +1 more source

Integração de imagens multitemporais e multissensores para mapeamento de café com google earth engine

Revista da ANPEGE
Esta pesquisa investigou a integração de imagens dos satélites Landsat 8 (L8), Sentinel-2 (S2) e Sentinel-1 (S1) com os índices de vegetação (NDVI, EVI, SAVI e NDWI).
Maria Cecilia Manoel, Alfredo Pereira de Queiroz, Marcos Reis Rosa   +2 more
doaj   +1 more source

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Rocavorexant, a novel, selective orexin‐1 receptor antagonist: Safety, tolerability and pharmacokinetics in healthy adults and individuals with opioid use disorder

British Journal of Clinical Pharmacology, EarlyView.
Aims Rocavorexant (INDV‐2000), a selective orexin‐1 receptor antagonist, reduces drug self‐administration and anxiety in nonclinical studies. This Phase 1 programme evaluated the safety, pharmacokinetics and pharmacodynamics of rocavorexant in healthy volunteers and treatment‐seeking individuals with opioid use disorder (OUD).
Martin Kankam, Rana Al‐Awam, Rajinder Shiwach, Andrew S. Huhn, Malcolm A. Young, Robert L. Dobbins   +5 more
wiley   +1 more source

Isolating T‐Cell Potent Lentiviral Vector Subpopulations through Rational Design of Nanofiber Anion‐Exchange Adsorbents

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Generation of CAR‐T cell therapies relies predominantly on lentiviral vectors (LVs). As in vivo CAR‐T trials progress, demand for larger quantities of higher‐potency LV is expected. However, primary capture by anion‐exchange chromatography (AIEX) remains a major manufacturing bottleneck from use of adsorbents not tailored to LVs, leading to ...
George Pamenter, Gyorgy Ovari, Anurag Kulkarni, Thomas Williams‐Fegredo, Carol Knevelman, Kyriacos Mitrophanous, Lee Davies, Farzad Foroutan, Matthew Townsend, Stephen Goldrick, Daniel G. Bracewell   +10 more
wiley   +1 more source

Ekstraksi Permukiman dari Kombinasi Citra Sentinel-2 dan Sentinel-1 dengan Pendekatan Object-Based Image Analysis

Journal of Geospatial Information Science and Engineering
Informasi yang akurat dan termutakhir mengenai data spasial permukiman skala menengah dibutuhkan berbagai bidang seperti agenda pembangunan berkelanjutan, perubahan iklim dan pengurangan risiko bencana. Namun, ekstraksi informasi spasial untuk permukiman
Dias Eramudadi, Catur Aries Rokhmana
doaj   +1 more source

Spectral imaging as a potential tool for optical sentinel lymph node biopsies

We investigate the potential use of spectral imaging for performing an optical sentinel lymph node biopsy. Dummy images generated from previously published data are analysed using a spectral angle map and we conclude that there is scope for spectral ...
Rutt, Harvey, O'Sullivan, Jack, Hoy, Paul   +2 more
core   +1 more source

Nurses attend a war rally, 1943

, 1943
Clipping from the June 22, 1943 issue of the Milwaukee Sentinel reporting on nurses attending a war rally sponsored by the American Legion. Pictured are Lt. Josephine Mersenski, South Milwaukee; Col.
Milwaukee Sentinel
core