Results 151 to 160 of about 4,607,292 (321)

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Malaria vector feeding, peak biting time and resting place preference behaviors in line with Indoor based intervention tools and its implication: scenario from selected sentinel sites of Ethiopia. [PDF]

Heliyon, 2022
Bedasso AH, Gutto AA, Waldetensai A, Eukubay A, Bokore GE, Kinde S, Gemechu F, Debebe Y, Aklilu M, Tasew G, Massebo F, Teshome A, Kebede T, Abdulatif B, Sisay A, Solomon H, Kweka EJ.   +16 more
europepmc   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Support for Integrated Ecosystem Assessments of NOAA’s National Estuarine Research Reserves System (NERRS), Volume I: The Impacts of Coastal Development on the Ecology and Human Well-being of Tidal Creek Ecosystems of the US Southeast [PDF]

, 2008
A study was conducted, in association with the Sapelo Island and North Carolina National Estuarine Research Reserves (NERRs), to evaluate the impacts of coastal development on sentinel habitats (e.g., tidal creek ecosystems), including potential impacts ...
Bergquist, D., Blair, A., Chapman, R., DiDonato, G., Jones, S., Riekerk, G., Sanger, D., Stewart, J., Vandiver, L., Washburn, T., Whitall, D., White, D., White, S., Wirth, E.   +13 more
core  

Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein–Antibody Interactions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier, Lukas Griesinger, Matthias Franzreb, Simon Kluters   +3 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac pathology and early indicators of cardiac risk

Clinical Epigenetics
Background Methylation changes linked to dilated cardiomyopathy (DCM) affect cardiac gene expression. We investigate DCM mechanisms regulated by CpG methylation using multi-omics and causal analyses in the largest cohort of left ventricular tissues ...
Konstanze Tan, Darwin Tay, Wilson Tan, Hong Kiat Ng, Eleanor Wong, Michael P. Morley, Gurpreet K. Singhera, Chang Jie Mick Lee, Pritesh R. Jain, Fei Li Tai, Paul J. Hanson, Thomas P. Cappola, Kenneth B. Margulies, Roger Foo, Marie Loh   +14 more
doaj   +1 more source

Combined gated graph convolution neural networks with multi-modal geospatial data for forest type classification

International Journal of Applied Earth Observations and Geoinformation
Forest type classification is essential for the monitoring and management of forests, with significant implications for environmental protection and the mitigation of climate change.
Huiqing Pei, Toshiaki Owari, Satoshi Tsuyuki, Takuya Hiroshima, Danfeng Hong   +4 more
doaj   +1 more source

Change detection in SAR time-series based on the coefficient of variation

, 2019
This paper discusses change detection in SAR time-series. Firstly, several statistical properties of the coefficient of variation highlight its pertinence for change detection. Then several criteria are proposed. The coefficient of variation is suggested
Koeniguer, Elise Colin, Nicolas, Jean-Marie   +1 more
core  

Fundamentals of Earth Observation Policy: Examples for German and European Missions [PDF]

, 2010
Several European countries have developed their national high resolution earth observation systems. Some of them are operated in close cooperation with industrial partners, others are dual-use missions earmarked to fulfil the needs of national security ...
Sandau, Rainer, Schmidt-Tedd, Bernhard, Schreier, Gunter   +2 more
core