Results 121 to 130 of about 2,175,214 (277)

Tips to avoid instrument separation in endodontics.

Journal of the Irish Dental Association, 2015
In the practice of endodontics, clinicians may encounter a variety of unwanted procedural accidents and obstacles to normally routine therapy, at almost any stage of treatment. One of these procedural problems is intracanal instrument fracture. Fractured root canal instruments may include endodontic files (Figure 1) and Gates Glidden burs.
openaire   +2 more sources

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Conservative Retrieval of a Separated Rotary Instrument from an Anterior Tooth Using an Ultrasonic Device and the Braiding Technique: A Clinical Case Report

Indian Journal of Dental Sciences
Instrument separation during root canal treatment can compromise canal debridement and adversely affect prognosis. Conservative retrieval is critical, especially in anterior teeth with limited dentin thickness.
Vidisha Katoch, Kulwant Rai, Shilpa Kumari, Umair Hussain Khan   +3 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Expert consensus on management of instrument separation in root canal therapy

International Journal of Oral Science
Instrument separation is a critical complication during root canal therapy, impacting treatment success and long-term tooth preservation. The etiology of instrument separation is multifactorial, involving the intricate anatomy of the root canal system ...
Yi Fan, Yuan Gao, Xiangzhu Wang, Bing Fan, Zhi Chen, Qing Yu, Ming Xue, Xiaoyan Wang, Zhengwei Huang, Deqin Yang, Zhengmei Lin, Yihuai Pan, Jin Zhao, Jinhua Yu, Zhuo Chen, Sijing Xie, He Yuan, Kehua Que, Shuang Pan, Xiaojing Huang, Jun Luo, Xiuping Meng, Jin Zhang, Yi Du, Lei Zhang, Hong Li, Wenxia Chen, Jiayuan Wu, Xin Xu, Jing Zou, Jiyao Li, Dingming Huang, Lei Cheng, Tiemei Wang, Benxiang Hou, Xuedong Zhou   +35 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source