Results 71 to 80 of about 486,743 (284)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Covering Numbers for Support Vector Machines [PDF]
, 1999 Support vector (SV) machines are linear classifiers that use the maximum margin hyperplane in a feature space defined by a kernel function. Until recently, the only bounds on the generalization performance of SV machines (within Valiant’s probably ...
Shawe-Taylor, John +7 more
core +2 more sources
General modeling of the windings for multi-phase ac machines [PDF]
, 2010 This paper, which deals with the winding modeling of ac multi-phase machines with a regular distribution of the stator slots, details an original matrix modeling of the stator winding.
CHARPENTIER, Jean-Frederic +8 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Acknowledgement to Reviewers of Machines in 2016
, 2017 The editors of Machines would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016.[...
Machines Editorial Office
core +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Acknowledgement to Reviewers of Machines in 2017
, 2018 The editors of Machines would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2017.[...
Machines Editorial Office
core +1 more source
Vectorial formalism for analysis and design of polyphase synchronous machines [PDF]
, 2003 A vectorial formalism for analysis and design of polyphase synchronous machines without reluctance and saturation effects is described. We prove the equivalence of such a machine with a set of magnetically independent machines, which are electrically and
BOUSCAYROL, Alain +5 more
core +1 more source