Results 261 to 270 of about 815,905 (331)

Population pharmacokinetics and optimized dosing of cefuroxime in critically ill patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cefuroxime is a second‐generation cephalosporin widely used in the intensive care unit (ICU). ICU patients have high variability in interpatient pharmacokinetics (PK), but the extent of this variation is unclear. We performed an observational PK study in ICU patients.
Jaap W. A. Mouton, Julian D. Machiels, Arthur M. A. Pistorius, Rob ter Heine, Tim Frenzel, Nynke G. L. Jager, Jeroen A. Schouten, Paddy K. C. Janssen, Rob E. Aarnoutse, Roger J. Brüggemann   +9 more
wiley   +1 more source

Diagnostic and Predictive Values of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis: A Multi-Center Prospective Clinical Study. [PDF]

J Inflamm Res
Wang K, Zhang Y, Sang L, Hu Y, Su L, Xie S, Xiao K, Xu J, Wang J, Xie F, Zhu G, Fu S, Xie L.   +12 more
europepmc   +1 more source

Probability of pharmacokinetic/pharmacodynamic target attainment for different piperacillin/tazobactam dosing regimens in renally impaired patients in a non‐intensive care unit setting

British Journal of Clinical Pharmacology, EarlyView.
Aims To optimize antibiotic therapy for pathogens classified as susceptible, increased exposure (I), an increased exposure of piperacillin/tazobactam (PTZ) is required. However, dosing recommendations are currently only available for patients with normal renal function.
Emma Dohmann, Stefan Hagel, Max Kurlbaum, Paul Schellong, Oliver Scherf‐Clavel, Güzin Surat   +5 more
wiley   +1 more source

Prevalence, pathogenic bacteria, and risk factors associated with pediatric sepsis among under five children in a rural district hospital in Rwanda. [PDF]

PLoS One
Orikiriza P, Ruhangaza D, Ayebare DS, Bizimana E, Niyibizi JB, Nshimiyimana I, Mujyuwisha L, Bekele A.   +7 more
europepmc   +1 more source

Multi-omics decodes host-specific and environmental microbiome interactions in sepsis. [PDF]

Front Microbiol
Lu J, Zhang W, He Y, Jiang M, Liu Z, Zhang J, Zheng L, Zhou B, Luo J, He C, Shan Y, Zhang R, Fan K, Fang B, Wan C.   +14 more
europepmc   +1 more source

Wastewater‐Based Epidemiology as a Complementary Tool for Antimicrobial Resistance Surveillance: Overcoming Barriers to Integration

BioEssays, EarlyView.
This commentary explores the potential of wastewater‐based epidemiology (WBE) as a complementary approach for antimicrobial resistance (AMR) surveillance. WBE may provide early, community‐level insights into resistance trends, supporting timely interventions.
José L. Balcázar
wiley   +1 more source

The Role of Protein Ubiquitination in the Onset and Progression of Sepsis. [PDF]

Cells
Chen MY, Liu Y, Fang M.
europepmc   +1 more source

PEGylation of polymerized albumin retains colloid osmotic pressure: Towards an enhanced potential plasma substitute

Biotechnology Progress, EarlyView.
Abstract Plasma expanders (PEs) are commonly used to replace lost blood volume for septic shock patients with increased vascular permeability. Human serum albumin (HSA) is the preferred PE, due to its innate ability to restore blood colloid osmotic pressure (COP).
Amna Abdalbaqi, Ahmad Yahya, Krianthan Govender, Carlos Muñoz, Gala Sanchez Van Moer, Daniela Lucas, Pedro Cabrales, Andre F. Palmer   +7 more
wiley   +1 more source

Early-Onset Neonatal Infection and Epilepsy in Children.

JAMA Netw Open
Andersen M, Matthiesen NB, Murra M, Nielsen SY, Henriksen TB.   +4 more
europepmc   +1 more source

Severe infection incidence among young infants in Dhaka, Bangladesh: an observational cohort study. [PDF]

BMJ Public Health
Fung A, Heasley C, Pell LG, Bassani DG, Shah PS, Morris SK, Hamer D, Islam MS, Mahmud AA, Pullenayegum E, Saha SK, Haque R, Hossain MI, Chen CY, Emdin A, O'Callaghan KM, Loutet MG, Sultana S, Billah SMM, Gaffar SMA, Karim E, Sayed S, Yeasmin S, Hoque MM, Ahmed T, Sarker SA, Roth DE.   +26 more
europepmc   +1 more source