Results 41 to 50 of about 107,014 (181)

Changes in left atrial deformation in hypertrophic cardiomyopathy: Evaluation by vector velocity imaging. [PDF]

, 2012
OBJECTIVES: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. We assessed the global and regional left atrial (LA) function and its relation to left ventricular (LV) mechanics ...
Badran, HM, Faheem, N, Hassan, H, Nazmy, A, Saadan, H, Soltan, G, Yacoub, MH   +6 more
core   +2 more sources

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Hypertrophic obstructive cardiomyopathy: alcohol septal ablation [PDF]

, 2017
Alcohol septal ablation (ASA) was introduced in 1994 as an alternative to septal myectomy for patients with hypertrophic obstructive cardiomyopathy and symptoms refractory to medical therapy.
Fifer, Michael A., Sigwart, Ulrich
core  

Association between postoperative nadir platelet count and postoperative cardiovascular complications following septal myectomy in patients with hypertrophic cardiomyopathy: a retrospective cohort study

BMC Cardiovascular Disorders
Platelet count is associated with cardiovascular risk and mortality in several cardiovascular diseases, but the association of the nadir platelet counts post-septal myectomy with the cardiovascular complication risk in hypertrophic obstructive ...
Qianqian Fan, Zhihong Lu, Yonghui Wang, Lini Wang, Hui Zhang, Ziyu Zheng, Hailong Dong, Lize Xiong, Chong Lei   +8 more
semanticscholar   +1 more source

Surgical treatment versus medical treatment in hypertrophic obstructive cardiomyopathy [PDF]

, 2017
Sixty-three patients operated upon for HOCM and 49 patients selected for non-surgical treatment have been followed-up for 15 years. Pre-operatively, surgical patients had a higher left ventricular outflow tract gradient at rest and, on the average, more ...
Gobet, D., Haberer, T., Krayenbuehl, H. P., Rothlin, M. E., Senning, Å., Turina, M.   +5 more
core  

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy. [PDF]

, 2014
Contraction in the mammalian heart is controlled by the intracellular Ca2+ concentration as it is in all striated muscle, but the heart has an additional signalling system that comes into play to increase heart rate and cardiac output during exercise or ...
Marston, SB, Messer, AE
core   +2 more sources

Early reverse remodeling of left heart morphology and function evaluated by cardiac magnetic resonance in hypertrophic obstructive cardiomyopathy after transapical beating-heart septal myectomy

Journal of Cardiovascular Magnetic Resonance, 2023
Purpose This study aimed to evaluate the early morphology and function of the left heart in hypertrophic obstructive cardiomyopathy (HOCM) after transapical beating-heart septal myectomy (TA-BSM) using cardiovascular magnetic resonance (CMR).
Yun Zhao, Chenhe Li, Dazhong Tang, Yi Luo, Chunlin Xiang, Lu Huang, Xiaoyue Zhou, Jing Fang, Xiang Wei, Liming Xia   +9 more
semanticscholar   +1 more source

Alcohol Septal Ablation in Hypertrophic Obstructive Cardiomyopathy: Long‐Term Follow‐Up of Deformations and Hemodynamics

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background A detailed evaluation of hemodynamics, supportive morphology, and deformation may help uncover the pathophysiology of hypertrophic obstructive cardiomyopathy (HOCM) and the changes wrought by alcohol septal ablation (ASA). Purpose To investigate the global cardiac volume, myocardial deformation, and hemodynamic characteristics ...
Kenichiro Suwa, Kazuto Ohno, Terumori Satoh, Ryota Sato, Keisuke Iguchi, Yuichiro Maekawa   +5 more
wiley   +1 more source

Septal myectomy for hypertrophic obstructive cardiomyopathy: coil, boil and the role of rescue surgery [PDF]

, 2017
Interventional treatment of hypertrophic obstructive cardiomyopathy has considerably developed and primary surgical approach is nowadays considered for a minority of patients with insufficient relief of obstruction following catheter intervention.
Carrel, Thierry, Schmidli, Jürg
core  

Decreased coronary flow reserve in hypertrophic cardiomyopathy is related to remodeling of the coronary microcirculation [PDF]

, 1998
BACKGROUND: Ischemia occurs frequently in hypertrophic cardiomyopathy (HCM) without evidence of epicardial stenosis. This study evaluates the hypothesis that the occurrence of ischemia in HCM is related to remodeling of the coronary ...
Birgelen, C. (Clemens) von, Carlier, S.G. (Stephan), Cate, F.J. (Folkert) ten, Duncker, D.J.G.M. (Dirk), Kliffen, M. (Mike), Kofflard, M.J.M. (Marcel), Krams, R. (Rob), Serruys, P.W.J.C. (Patrick)   +7 more
core   +1 more source