Results 41 to 50 of about 49,264 (163)

Efficacy and safety of myectomy and radiofrequency septal ablation for treating hypertrophic obstructive cardiomyopathy

Open Heart
Background Novel treatments are needed for patients with severely symptomatic obstructive hypertrophic cardiomyopathy (oHCM). Radiofrequency (RF) septal ablation has emerged as a promising technique for improving the left ventricular outflow tract (LVOT)
Larissa Ventura Ribeiro Bruscky, Bruno Pereira Valdigem, Edileide de Barros Correia, Paulo Chaccur, Andrea de Andrade Vilela, Antônio Tito Paladino Filho, Ibraim Pinto, Rui Fernando Ramos, Jorge Eduardo Assef   +8 more
doaj   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Video_1_Thoracoscopic Trans-mitral Septal Myectomy for Hypertrophic Obstructive Cardiomyopathy in the Elderly.MP4

, 2022
BackgroundThe thoracoscopic trans-mitral approach can not only facilitate exposure of the ventricular septum, mitral valve, and subvalvular apparatus, it also enables the surgeons to perform concomitant mitral valve intervention.
Zhao Chen (92571), Peijian Wei (12214859), Jian Liu (33711), Jiexu Ma (12214862), Huiming Guo (3526940), Jimei Chen (3154692), Jian Zhuang (386570), Hongxiang Wu (2560804), Wei Zhu (23646), Tong Tan (12214865), Yanjun Liu (367302)   +10 more
core   +1 more source

Systolic anterior motion of the mitral valve associated with acute type A aortic dissection: a case report describing one-step surgery of ascending aortic replacement and interventricular septal myectomy

Surgical Case Reports, 2021
Background Systolic anterior motion of the mitral valve associated with acute type A aortic dissection is rare in daily clinical practice. The prevention of systolic anterior motion is important, because once it occurs, the hemodynamics may become ...
Naoki Yamamoto, Koji Onoda
doaj   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Treatment modalities in hypertrophic obstructive cardiomyopathy: Surgical myectomy versus percutaneous septal ablation

, 2007
Background: The aim of this study was to compare the results of percutaneous septal myocardial ablation (PSMA) and surgical myectomy (SM) for decreasing the left ventricular outflow tract (LVOT) gradient, septal thickness, ventricular dimensions, and ...
Oezyazicioglu, Ahmet, Serhat Yalçinkaya, Ata, Yusuf, Yusuf Ata, Ahmet Özyazicioğlu, ERKUT, Bilgehan, Tamer Türk, Tuerk, Tamer, Tiryakioglu, Osman, Yalcinkaya, SERHAT, Bozat, Tahsin, Bilgehan Erkut, Vural, A. Hakan, Ari, Hasan, A. Hakan Vural, Tahsin Bozat, Osman Tiryakioğlu, Hasan Ari   +17 more
core   +1 more source

Comparing long‐term outcomes of septal myectomy and mitral valve replacement in hypertrophic cardiomyopathy patients: A retrospective cohort study in Iran

Health Science Reports
Background Hypertrophic cardiomyopathy (HCM) affects millions of individuals worldwide. In severe cases, it can cause life‐threatening conditions such as left ventricular outflow tract (LVOT) obstruction, mitral regurgitation (MR), and sudden cardiac ...
Aryan Ayati, Mehran Khoshfetrat, Saeed Davoodi, Seyed Hossein Ahmadi Tafti, Reza Arefizadeh   +4 more
doaj   +1 more source

Key Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review

Movement Disorders, Volume 41, Issue 10, Page 2564-2591, October 2026.
Abstract Friedreich's ataxia (FA) is a rare neurodegenerative disease with multisystemic symptoms that requires multidisciplinary care. This systematic review summarizes available pharmacological and nonpharmacological interventions, their outcomes, and alignment with patient‐centered care domains, as well as their impact on these domains.
Dorota Sarwinska, Maresa Buchholz, Audrey Iskandar, Marcus Grobe‐Einsler, Thomas Klockgether, Jennifer Faber, Bernhard Michalowsky   +6 more
wiley   +1 more source

A new technique to avoid the intraoperative complications of septal myectomy in patients with obstructive hypertrophic cardiomyopathy

, 2009
Although transaortic septal myectomy in obstructive hypertrophic cardiomyopathy (OHC) is accepted as a safe procedure, it may end up with serious peroperative complications.
Celebi, Serdar, Omay, Oguz, Suzer, Kaya, Ozgol, Ilhan, Ozker, Emre   +4 more
core   +1 more source

Outcomes of Septal Myectomy beyond 65 Years, with and without Concomitant Procedures

, 2021
Introduction and objectives: Septal myectomy remains the first septal reduction therapy for hypertrophic obstructive cardiomyopathy in young patients and those requiring concomitant procedures.
Juan Perdomo, Cristina Ibáñez, Paloma Jordà, Clemente Barriuso, Robert Pruna-Guillen, Jorge Alcocer, Ana García-Álvarez, Daniel Pereda, Elena Sandoval, Alessandro Affronti, Susanna Prat-González, Eduard Quintana, Manuel Castellà, Jaume Llopis   +13 more
core   +1 more source