Results 121 to 130 of about 5,703,192 (247)

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Case report: Light-chain amyloidosis responsive to selinexor in combination with daratumumab and dexamethasone (SDd) therapy

Frontiers in Medicine
The outcome of AL amyloidosis remains poor, particularly in patients with advanced organ involvement which takes long time to recovery. We conducted an observational study of two patients with AL amyloidosis treated with SDd regimen.
Xiaolu Long, Ning An, Chunhui Li, Hui Zhu, Haojie Li, Qiuxia Yu, Yimei Que, Menglei Xu, Zhe Li, Wei Chen, Shuai Wang, Di Wang, Di Wang, Chunrui Li, Chunrui Li   +14 more
doaj   +1 more source

Transcatheter closure of symptomatic aortopulmonary window in an infant [PDF]

, 2008
An aortopulmonary window is a rare congenital cardiac defect. In the majority of symptomatic neonates and infants, primary surgical repair is the treatment of choice.
Brockmeier, Konrad, Sreeram, Narayanswami, Pillekamp, Frank, Hannes, Tobias, Koch, Daniel   +4 more
core  

CYP3A5 genetic variability influences sildenafil and metabolite in pulmonary hypertension

British Journal of Clinical Pharmacology, EarlyView.
Aim Interindividual variability in sildenafil response among pulmonary hypertension patients (PH) may be influenced by CYP3A5 polymorphisms. CYP3A5*3 allele reduces CYP3A5 activity and affects sildenafil metabolism. This study investigated the associations between CYP3A5 genotype and plasma concentrations of sildenafil and N‐desmethyl sildenafil, as ...
Pranisa Wongwien, Burabha Pussadhamma, Sirimas Kanjanawart, Thikhumporn Areesinpitak, Nontaya Nakkam, Chingching Foocharoen, Wichittra Tassaneeyakul, Suda Vannaprasaht   +7 more
wiley   +1 more source

Electron compensation‐gated nanomotor for immunomodulation and microenvironment remodeling in bacterial pneumonia therapy

BMEMat, EarlyView.
A nanomotor featuring an “electronic lock” via electron compensation in an Au‐Ag alloy ensures therapeutic precision. Near‐infrared light acts as a key, unlocking on‐demand Ag+ release for synergistic bactericidal action and microenvironment remodeling to potently treat bacterial pneumonia. Abstract Bacterial pneumonia treatment is severely hampered by
Chenglong Xue, Xiaoyu Zhao, Yuqian Wang, Lijin Shi, Qi Shuai   +4 more
wiley   +1 more source

Atrial septal defect closure in a patient with "irreversible" pulmonary hypertensive arteriopathy

, 2006
The presence of irreversible pulmonary hypertension in patients with atrial septal defect (ASD) is thought to preclude shunt closure. We report the case of a woman with plexiform pulmonary arteriopathy secondary to an ostium secundum ASD who was able to ...
Zafar, Moiz, Webb, Gary, McLaughlin, Peter R, Granton, John, Schwerzmann, Markus, Chamberlain, Dean W   +5 more
core   +1 more source

Tooth autotransplantation following extraction of periodontally hopeless teeth in a periodontitis patient

Clinical Advances in Periodontics, EarlyView.
Abstract Background The aim of the study is to report clinical outcomes of autogenous tooth transplantation (ATT) of fully developed third molars following the extraction of periodontally hopeless teeth as a part of the treatment of a stage III, grade C, molar‐incisor pattern (MIP) periodontitis case.
Alessandro Rizzi, Giorgia Astolfi, Roberto Farina, Leonardo Trombelli   +3 more
wiley   +1 more source

A Large Retrospective Study to Evaluate Utility of Zephyr Covered Stent in Transcatheter Closure of Sinus Venosus Defects

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Transcatheter closure (TCC) of sinus venosus defects (SVD) using balloon‐expandable covered stents is an emerging alternative to surgery. ZephyrCS (Sahajanand Laser Technologies, Gandhinagar, India) is available in long lengths to suit SVD closure.
Pramod Sagar, Puthiyedath Thejaswi, Kothandam Sivakumar, Praveen Ashok Kumar   +3 more
wiley   +1 more source

Right ventricular septal pacing as alternative for failed left ventricular lead implantation in cardiac resynchronization therapy candidates

, 2015
To compare the effects on left ventricular (LV) function of right ventricular (RV) septal pacing vs. cardiac resynchronization therapy (CRT) in patients with an indication for the latter.
Broadhurst, Paul A, Hannah, Andrew, Hillis, Graham S, Frenneaux, Michael, Small, Gary R, Alhous, M Hafez A   +5 more
core   +1 more source

Percutaneous Left Atrial Appendage Closure Using a PFO Occluder After an Incomplete Surgical Ligation

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT The case regards a 73‐year‐old male who was referred for consideration of percutaneous left atrial appendage closure. His left atrial appendage was ligated during prior mitral valve surgery, but was noted to be patent on a recent transesophageal echocardiography. An Amulet device was selected based on CT planning.
Zach Rozenbaum, Eric Gnall
wiley   +1 more source