Results 101 to 110 of about 44,179 (214)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Long‐Term Clinical Outcomes of Arthroscopic Suture Anchor Fixation of Bony Bankart Lesions at a Mean 18‐Year Follow‐Up

Arthroscopy, EarlyView.
Purpose To evaluate shoulder stability and function at long‐term follow‐up after arthroscopic single‐row suture anchor fixation of bony Bankart lesions. Methods This was a retrospective, single‐center study. Patients with anterior glenoid rim fractures after traumatic shoulder instability who underwent arthroscopic single‐row suture anchor fixation for
Malik Jessen, Maximilian Hinz, Johannes Plath, Bastian Scheiderer, Sebastian Siebenlist, Lucca Lacheta   +5 more
wiley   +1 more source

Peak Serum Vancomycin Levels Are Achieved Between 6 and 24 Hours After Implantation of Vancomycin‐Soaked Anterior Cruciate Ligament Grafts

Arthroscopy, EarlyView.
Purpose To examine systemic exposure and elution characteristics of liquid vancomycin‐soaked anterior cruciate ligament (ACL) grafts in vivo by assessing serum vancomycin levels over 48 hours after ACL reconstruction and comparing the resulting concentrations with the toxic threshold of 15 to 20 μg/mL.
Swen Witteveen, Steffen T. Ubl, Sophia Krombholz, Daniel Guenther, Carolin Flieser, Arasch Wafaisade, Bertil Bouillon, Mario Thevis, Thomas R. Pfeiffer   +8 more
wiley   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Diabetes Mellitus Is Associated With Increased Risk for Subsequent Hip Arthroscopy After Index Hip Arthroscopy

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To determine whether diabetes mellitus is associated with higher systemic and hip‐specific complications and to evaluate reoperation rates after hip arthroscopy. Methods Using the TriNetX Research Network and Current Procedural Terminology and International Classification of Diseases codes, we identified diabetic and nondiabetic patients aged ...
Nicholas J. Morriss, Justin Harrington, Jacob Waldron, Brian Giordano   +3 more
wiley   +1 more source

Recurrent Lelliottia amnigena Septic Arthritis in an Immunocompetent Child. [PDF]

Cureus
Kooistra J, Eisenhardt M, Christenson JC, Mayhew JA.   +3 more
europepmc   +1 more source

Artificial Intelligence Predicts Failure of Nonoperative Treatment in Degenerative Posterosuperior Rotator Cuff Tears

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To develop an artificial intelligence‐based algorithm to predict success of nonoperative treatment in degenerative posterosuperior tears and to identify the most influential features. Methods Patients with degenerative rotator cuff tears initially treated nonoperatively were enrolled prospectively from January 2022 to November 2024.
Santiago Gabardo, Natalia Martínez‐Catalán, José María Belmonte Martínez, Gregorio Bernabé García, José Manuel García Carrasco, Cristina Delgado, María Valencia‐Mora, Gonzalo Luengo‐Alonso, Emilio Calvo   +8 more
wiley   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Crowned Dens Syndrome Mimicking Septic Arthritis in a Renal Transplant Recipient. [PDF]

Cureus
Praveen Nair H, Butt H, Au M, Heaney J.
europepmc   +1 more source