Results 141 to 150 of about 83,060 (353)
Advanced Science, EarlyView.FeCo dual‐atom catalyst (FeCo‐N‐DAC) with ultrahigh metal loading (Fe > 5.4%, Co > 4.8%) is developed for synergistic photothermal‐chemodynamic immunotherapy. FeCo‐N‐DAC penetrates deep‐seated tissues, eradicates MRSA biofilms, and reprograms immune‐inflammatory pathways via multi‐omics‐validated mechanisms.
Shihao Xu +11 more
wiley +1 more source
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1
Advanced Science, EarlyView.Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang +10 more
wiley +1 more source
Adult native septic arthritis: a review of 10 years of experience and lessons for empirical antibiotic therapy [PDF]
, 2017 Objectives To review the epidemiology of native septic arthritis to establish local guidelines for empirical antibiotic therapy as part of an antibiotic stewardship programme.
Clerc, Olivier +4 more
core
Advanced Science, EarlyView.We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang +10 more
wiley +1 more source
In the eye of the storm: T cell behavior in the inflammatory microenvironment. [PDF]
, 2013 Coordinated unfolding of innate and adaptive immunity is key to the development of protective immune responses. This functional integration occurs within the inflamed tissue, a microenvironment enriched with factors released by innate and subsequently ...
Haas, R, Marelli-Berg, F, Mauro, C
core +1 more source
Scedosporium prolificans Septic Arthritis [PDF]
, 2016 Jessica Frankenhoff +2 more
openalex +1 more source
CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target
Advanced Science, EarlyView.This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang +2 more
wiley +1 more source
Meningitis or septicaemia in a backpacker? [PDF]
, 2015 Negative blood test results for meningitis but positive for Staphylococcus aureus in a young patient with suspected meningitis and a recent joint injury led to a diagnosis of staphylococcal septicaemia with septic arthritis as the source of the ...
Fulde, Gordian, Fulde, Sascha
core +1 more source
A potential key role for alpha-haemolysin of Staphylococcus aureus in mediating chondrocyte death in septic arthritis [PDF]
, 2018 I.D.M. Smith +5 more
openalex +1 more source