Results 71 to 80 of about 303,388 (291)
Advanced Science, EarlyView.Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu +11 more
wiley +1 more source
A Fish MDA5 Integrates Canonical RIG‐I and MDA5 Ligand Recognition
Advanced Science, EarlyView.These results show that the large yellow croaker lacks RIG‐I, yet its MDA5 senses both 5′ppp‐dsRNA and long dsRNA. A flexible RNA‐capping loop in the MDA5 C‐terminal domain enables two ligand‐binding modes. This dual recognition signals through MAVS–STING–TBK1/IRF3 and induces type I interferons, revealing unexpected plasticity in vertebrate antiviral ...
Wenxing Li +7 more
wiley +1 more source
Advanced Science, EarlyView.BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang +7 more
wiley +1 more source
A Bioinspired Underwater Soft Robot for Active Intravesical Liquid Delivery and Mixing
Advanced Intelligent Systems, EarlyView.A bioinspired underwater soft robot is reported that integrates an elastic strain energy‐driven soft robotic pump with a programmable flexible magnetic valve, enabling remotely controlled, programmable, and sustained liquid release and mixing. This functionality is enabled by the synergistic integration of elastic strain energy‐driven pumping and ...
Jacob Katona +7 more
wiley +1 more source
The most common wastewater treatment system used in rural areas is the septic tank-soil absorption system. The septic tank removes settlable and floatable solids from the wastewater, and the soil absorption field filters and treats the clarified septic ...
Moore, James A. (James Allan), 1939- +1 more
core +2 more sources
Septic tank design section B-B
, 2019 Septic tank design section B-
Rod Shaw (1258020) +3 more
core +1 more source
Australian Journal of Social Issues, EarlyView.ABSTRACT In her 2024 paper Are Australian students' academic skills declining? Interrogating 25 years of national and international standardised assessment data, Larsen compiled an impressive summary of major international (PISA, PIRLS and TIMSS) and national (NAPLAN) standardised assessments pertaining to literacy and numeracy.
Pamela C. Snow +9 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang +12 more
wiley +1 more source
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
Animal Research and One Health, EarlyView.A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang +10 more
wiley +1 more source
Septic tank access and groundwater status.
, 2020 Septic tank access and groundwater status.
Olivia Jensen (8487105) +1 more
core +1 more source