Results 51 to 60 of about 252 (120)

Encoding Patterned Spatial Behavior in the Subiculum

Hippocampus, Volume 36, Issue 3, May 2026.
ABSTRACT The subiculum, a key component of the medial temporal lobe (MTL), has traditionally been viewed as a relay station for hippocampal output to cortical regions. However, its intricate afferent and efferent connections with diverse brain areas suggest a more independent role in memory and spatial navigation.
Su‐Min Lee, Inah Lee
wiley   +1 more source

Hilar granule cells of the mouse dentate gyrus: effects of age, septotemporal location, strain, and selective deletion of the proapoptotic gene BAX [PDF]

Brain Structure and Function, 2017
The dentate gyrus (DG) principal cells are glutamatergic granule cells (GCs), and they are located in a compact cell layer. However, GCs are also present in the adjacent hilar region, but have been described in only a few studies. Therefore, we used the transcription factor prospero homeobox 1 (Prox1) to quantify GCs at postnatal day (PND) 16, 30, and ...
Keria Bermudez-Hernandez, Yi-Ling Lu, Jillian Moretto, Swati Jain, John J. LaFrancois, Aine M. Duffy, Helen E. Scharfman   +6 more
openaire   +2 more sources

Tacrolimus (FK506) reduces ischemia-induced hippocampal damage in rats: a 7- and 30-day study

Brazilian Journal of Medical and Biological Research, 2003
The neuroprotective effect of the immunosuppressant agent FK506 was evaluated in rats after brain ischemia induced for 15 min in the 4-vessel occlusion model.
F. Giordani, A. Benetolli, L.A. Favero-Filho, K.C.M. Lima, L. Cestari Junior, H. Milani   +5 more
doaj   +1 more source

Layer‐Specific Astrocyte Morphological Responses in the CA3 Hippocampus Region During Piry Virus‐Induced Encephalitis

Hippocampus, Volume 36, Issue 2, March 2026.
ABSTRACT Astrocytes from distinct hippocampal layers exhibit region‐specific morphological traits, which may be influenced by their local microenvironment. During viral encephalitis, these cells undergo dynamic changes that can reflect layer‐specific vulnerability. In this study, we characterized whether astrocytes from different CA3 hippocampal layers
Diego de Almeida Miranda, Aline Andrade de Sousa, Renata Rodrigues dos Reis, Zaire Alves dos Santos, José Antonio Picanço Diniz, Pedro Fernando da Costa Vasconcelos, Cristovam Guerreiro Diniz, Daniel Clive Anthony, Dora Brites, Cristovam Wanderley Picanço Diniz, Daniel Guerreiro Diniz   +10 more
wiley   +1 more source

Novel space alters theta and gamma synchrony across the longitudinal axis of the hippocampus

Frontiers in Systems Neuroscience, 2013
Hippocampal theta (6-10 Hz) and gamma (25-50 Hz and 65-100 Hz) local field potentials reflect the dynamic synchronization of inputs impinging upon hippocampal neurons.
stephanie c penley, james r hinman, lauren l long, etan j markus, monty a escabi, monty a escabi, james j chrobak   +6 more
doaj   +1 more source

Non‐Canonical Subiculum Circuit Organization and Function

Hippocampus, Volume 36, Issue 2, March 2026.
ABSTRACT The subiculum is highly interconnected with the hippocampus, sub‐regions of the thalamus, and the entorhinal and retrosplenial cortices. Together, these regions form a distributed network that plays critical roles in spatial cognition and learning and memory.
Pan Gao, Wenhao Cao, Douglas A. Nitz, Xiangmin Xu   +3 more
wiley   +1 more source

Seizure-induced motility of differentiated dentate granule cells is prevented by the central Reelin fragment

Frontiers in Cellular Neuroscience, 2016
Granule cell dispersion (GCD) represents a pathological widening of the granule cell layer (GCL) in the dentate gyrus and it is frequently observed in patients with mesial temporal lobe epilepsy (MTLE).
Catarina Orcinha, Catarina Orcinha, Catarina Orcinha, Catarina Orcinha, Gert Münzner, Gert Münzner, Gert Münzner, Johannes Gerlach, Johannes Gerlach, Johannes Gerlach, Antje Kilias, Antje Kilias, Antje Kilias, Marie Follo, Marie Follo, Ulrich Egert, Ulrich Egert, Carola A Haas, Carola A Haas, Carola A Haas, Carola A Haas   +20 more
doaj   +1 more source

Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Memories of rewarding experiences powerfully shape behavior, yet when maladaptive, they can drive psychiatric conditions including addiction, depression, and PTSD. Memory traces, or engrams, have been extensively studied for fear memories in the hippocampal dentate gyrus.
Lorianna M. Colón, Oluwatoni A. Famuyide, Amelia J. Eisch   +2 more
wiley   +1 more source

Endogenous ACh effects on NMDA‐induced interictal‐like discharges along the septotemporal hippocampal axis of adult rats and their modulation by an early life generalized seizure [PDF]

Epilepsia, 2012
SummaryPurpose: Our earlier findings of the modulation of cholinergic neurotransmission by an early life generalized seizure and the reported interaction between muscarinic andN‐methyl‐d‐aspartate (NMDA) receptors prompted us to investigate the effects of endogenous acetylcholine (ACh) on the frequency (Hz) of the epileptiform discharges following NMDA‐
Mikroulis, Apostolos V., Psarropoulou, Caterina   +1 more
openaire   +3 more sources

Septotemporal‐specific Effects of a Gulf War Illness Sarin Surrogate, Diisopropylfluorophosphate, on Synaptic Transmission in the Mouse Hippocampus

The FASEB Journal, 2019
Diisopropylfluorophosphate (DFP) is a common surrogate for nerve agents used in rodent models of Gulf War Illness (GWI) and is known to alter hippocampal synaptic transmission. Although there has been an increased appreciation for functional differences in the hippocampus between the dorsal (dH) and ventral (vH) sectors, there is a
Kyle A Brown, Nikolay M Filipov, John J Wagner   +2 more
openaire   +1 more source