Results 21 to 30 of about 248,838 (167)

Evaluation of Transdermal Transport and Concurrent Cutaneous Hydrolysis of Timolol Prodrug for the Treatment of Infantile Hemangiomas

Pharmaceutics, 2022
Infantile hemangiomas (IH) leave sequelae after involution. Topical application of timolol maleate (TM) is the mainstream treatment for superficial lesions but is limited by its low penetrable properties.
Shih-Jen Chang, Huiyuan Wang, Jialin Chen, Qianyi Chen, Lei Chang, Yongzhuo Huang, Yajing Qiu, Xiaoxi Lin   +7 more
doaj   +1 more source

Diagnostic SARS-CoV-2 Cycle Threshold Value Predicts Disease Severity, Survival, and Six-Month Sequelae in COVID-19 Symptomatic Patients

Viruses, 2021
To date, there is no severe acute respiratory syndrome coronavirus 2-(SARS-CoV-2)-specific prognostic biomarker available. We assessed whether SARS-CoV-2 cycle threshold (Ct) value at diagnosis could predict novel CoronaVirus Disease 2019 (COVID-19 ...
Mattia Trunfio, Francesco Venuti, Francesca Alladio, Bianca Maria Longo, Elisa Burdino, Francesco Cerutti, Valeria Ghisetti, Roberto Bertucci, Carlo Picco, Stefano Bonora, Giovanni Di Perri, Andrea Calcagno   +11 more
doaj   +1 more source

Complication and Sequelae of COVID-19: What Should We Pay Attention to in the Post-Epidemic Era

Frontiers in Immunology, 2021
COVID-19 is widespread worldwide and seriously affects the daily life and health of humans. Countries around the world are taking necessary measures to curb the spread. However, COVID-19 patients often have at least one organ complication and sequelae in
Keda Yang, Guangfu Wen, Jinpeng Wang, Siming Zhou, Wacili Da, Yan Meng, Yuchuan Xue, Lin Tao   +7 more
doaj   +1 more source

Upregulation of DDAH2 Limits Pulmonary Hypertension and Right Ventricular Hypertrophy During Chronic Hypoxia in Ddah1 Knockout Mice

Frontiers in Physiology, 2020
Objective: Chronic hypoxia causes pulmonary vasoconstriction leading to pulmonary hypertension and right ventricular hypertrophy. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis; its level increases in hypoxia
Juliane Hannemann, Juliane Hannemann, Antonia Glatzel, Jonas Hillig, Jonas Hillig, Julia Zummack, Julia Zummack, Udo Schumacher, Nicole Lüneburg, Lars Harbaum, Rainer Böger, Rainer Böger   +11 more
doaj   +1 more source

Long-term clinical follow-up of patients suffering from moderate-to-severe COVID-19 infection: a monocentric prospective observational cohort study

International Journal of Infectious Diseases, 2021
: Objectives: Various symptoms and considerable organ dysfunction persist following infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Uncertainty remains about the potential mid- and long-term health sequelae. This prospective
Gilles Darcis, Antoine Bouquegneau, Nathalie Maes, Marie Thys, Monique Henket, Florence Labye, Anne-Françoise Rousseau, Perrine Canivet, Colin Desir, Doriane Calmes, Raphael Schils, Sophie De Worm, Philippe Léonard, Paul Meunier, Michel Moutschen, Renaud Louis, Julien Guiot   +16 more
doaj   +1 more source

Asymmetric Dimethylarginine at Sea Level Is a Predictive Marker of Hypoxic Pulmonary Arterial Hypertension at High Altitude

Frontiers in Physiology, 2019
Background: Prolonged exposure to altitude-associated chronic hypoxia (CH) may cause high-altitude pulmonary hypertension (HAPH). Chronic intermittent hypobaric hypoxia (CIH) occurs in individuals who commute between sea level and high altitude.
Patricia Siques, Patricia Siques, Julio Brito, Julio Brito, Edzard Schwedhelm, Eduardo Pena, Eduardo Pena, Fabiola León-Velarde, Fabiola León-Velarde, Juan José De La Cruz, Rainer H. Böger, Rainer H. Böger, Juliane Hannemann, Juliane Hannemann   +13 more
doaj   +1 more source

Medical Management after Lancehead Snakebite in North Amazon: A Case Report of Long-Term Disability

Toxins, 2022
Snakebites are a major public health problem in indigenous communities in Brazil, leading to acute local and systemic damage with resulting deficiencies. Long-term musculoskeletal disabilities related to snakebites have been a neglected area of research.
Isadora S. Oliveira, Carla B. Ananias, Jilvando M. Medeiros, Michelle V. S. Franco, Isabela G. Ferreira, Felipe A. Cerni, Eliseu A. Sandri, Wuelton M. Monteiro, Manuela B. Pucca   +8 more
doaj   +1 more source

Case Report: Pirfenidone in the Treatment of Post-COVID-19 Pulmonary Fibrosis

Frontiers in Medicine, 2022
BackgroundPulmonary fibrosis is one of the sequelae of the COVID-19, which seriously affects the quality of life of survivors. Currently, there are no optimal evidence based guidelines targeting this population.Case PresentationWe report a 66-year-old ...
Xianglin Zhou, Xianglin Zhou, Xianglin Zhou, Danhui Yang, Danhui Yang, Danhui Yang, Xianglong Kong, Chengli Wei, Chengli Wei, Chengli Wei, Siqi LvQiu, Siqi LvQiu, Siqi LvQiu, Lin Wang, Lin Wang, Lin Wang, Yongkang Lin, Yongkang Lin, Yongkang Lin, Zhilan Yin, Zhiguo Zhou, Hong Luo, Hong Luo, Hong Luo   +23 more
doaj   +1 more source

Sequelae from meningococcal meningitis in children: a critical analysis of dexamethasone therapy Seqüelas de meningite meningocócica em crianças: análise crítica da utilização da dexametasona

Arquivos de Neuro-Psiquiatria, 2004
OBJECTIVE: To evaluate the effectiveness of dexamethasone as an adjunctive therapy to antibiotics in children with meningococcal meningitis. METHOD: A total of 81 children diagnosed with meningococcal meningitis hospitalized in sequence were studied at ...
Erasmo Barbante Casella, Saul Cypel, André Alexandre Osmo, Yassuhiko Okay, Beatriz Helena Lefèvre, Ida Lichtig, Maria Joaquina Marques-Dias   +6 more
doaj   +1 more source

Sequelae and Animal Modeling of Encephalitic Alphavirus Infections

Viruses, 2023
Eastern (EEEV), Venezuelan (VEEV), and western equine encephalitis viruses (WEEV) are members of the genus Alphavirus, family Togaviridae. Typically spread by mosquitoes, EEEV, VEEV, and WEEV induce febrile illness that may develop into more severe ...
Rachel A. Reyna, Scott C. Weaver
doaj   +1 more source