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Multiple Sequence Alignment [PDF]
, 2016 The increasing importance of Next Generation Sequencing (NGS) techniques has highlighted the key role of multiple sequence alignment (MSA) in comparative structure and function analysis of biological sequences. MSA often leads to fundamental biological insight into sequence-structure-function relationships of nucleotide or protein sequence families ...
K. Anton Feenstra +5 more
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Ggmsa: a Visual Exploration Tool for Multiple Sequence Alignment and Associated Data
Briefings Bioinform., 2022The identification of the conserved and variable regions in the multiple sequence alignment (MSA) is critical to accelerating the process of understanding the function of genes.
Lang Zhou +12 more
semanticscholar +1 more source
Linear Sequence-to-Sequence Alignment
IEEE Transactions on Pattern Analysis and Machine Intelligence, 2004In this paper, we consider the problem of estimating the spatiotemporal alignment between N unsynchronized video sequences of the same dynamic 3D scene, captured from distinct viewpoints. Unlike most existing methods, which work for N = 2 and rely on a computationally intensive search in the space of temporal alignments, we present a novel approach ...
G.A.M.R. Santos +3 more
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T-Coffee: A novel method for fast and accurate multiple sequence alignment.
Journal of Molecular Biology, 2000We describe a new method (T-Coffee) for multiple sequence alignment that provides a dramatic improvement in accuracy with a modest sacrifice in speed as compared to the most commonly used alternatives.
C. Notredame, D. Higgins, J. Heringa
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Current Opinion in Structural Biology, 2006
Multiple sequence alignments are an essential tool for protein structure and function prediction, phylogeny inference and other common tasks in sequence analysis. Recently developed systems have advanced the state of the art with respect to accuracy, ability to scale to thousands of proteins and flexibility in comparing proteins that do not share the ...
Robert C. Edgar, Serafim Batzoglou
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Multiple sequence alignments are an essential tool for protein structure and function prediction, phylogeny inference and other common tasks in sequence analysis. Recently developed systems have advanced the state of the art with respect to accuracy, ability to scale to thousands of proteins and flexibility in comparing proteins that do not share the ...
Robert C. Edgar, Serafim Batzoglou
openaire +2 more sources
Journal of Molecular Biology, 1986
A method has been developed for aligning segments of several sequences at once. The number of search steps depends only polynomially on the number of sequences, instead of exponentially, because most alignments are rejected without being evaluated explicitly. A data structure herein called the "heap" facilitates this process.
David J. Bacon, Wayne F. Anderson
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A method has been developed for aligning segments of several sequences at once. The number of search steps depends only polynomially on the number of sequences, instead of exponentially, because most alignments are rejected without being evaluated explicitly. A data structure herein called the "heap" facilitates this process.
David J. Bacon, Wayne F. Anderson
openaire +3 more sources
2003
Publisher Summary This chapter discusses various aspects of multiple sequence alignment. Dynamic programming can be generalized to more than two sequences where one finds the multiple alignments with the best score according to the scoring scheme. Gaps are scored according to their length and the number of sequences that they occur in and the method ...
Desmond G. Higgens, William R. Taylor
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Publisher Summary This chapter discusses various aspects of multiple sequence alignment. Dynamic programming can be generalized to more than two sequences where one finds the multiple alignments with the best score according to the scoring scheme. Gaps are scored according to their length and the number of sequences that they occur in and the method ...
Desmond G. Higgens, William R. Taylor
openaire +5 more sources