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The chemistry of protein sequence analysis

2000
N-terminal sequence analysis by Edman chemistry continues to play an important role in the structural analysis of proteins and peptides. Improvements in the sensitivity of the method have been achieved mainly at the level of increasing the sensitivity of the on-line analysis of PTH amino acids by RP-HPLC (reverse phase high performance chromatography).
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PROTEAN: Protein Sequence Analysis and Prediction

Molecular Biotechnology, 2000
The archaeal, bacterial, andeukaryotic genome projects have overwhelmed our ability to experimentally elucidate the function of each novel gene and gene product. To a certain extent, protein functional assignments can be derived via sequence similarity measures and direct primary sequence analysis using methods to predict hydropathy, secondary ...
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Analysis of similarity/dissimilarity of protein sequences

Proteins: Structure, Function, and Bioinformatics, 2008
AbstractOn the basis of a selected pair of physicochemical properties of amino acids, we introduce a dynamic 2D graphical representation of protein sequences. Then, we introduce and compare two numerical characterizations of protein graphs as descriptors to analyze the nine ND5 proteins. The approach is simple, convenient, and fast.
Chun Li   +5 more
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Sequence Analysis by Numbers: Proteins

Polymer-Plastics Technology and Engineering, 1996
Abstract As a number code to the protein sequence language, the amino acid numbers (z) derived previously (1, 25, 45, and 17 prime numbers smaller than 64) are used to characterize oligopeptide motifs. The grammatical rule of this language is expressed with two theorems governing the collective properties of oligopeptides.
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Compact Protein Sequencer for the C-Terminal Sequence Analysis of Peptides and Proteins

Analytical Biochemistry, 1993
We describe the construction of a compact protein sequencer designed specifically for the C-terminal sequence analysis of peptides and proteins. This sequencer has a vertical flow path and is equipped with a continuous flow reactor (CFR). The flow paths for the various reagents and solvents have been minimized.
M. Rusnak, J.M. Bailey, John E. Shively
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Chance and statistical significance in protein and DNA sequence analysis.

Science, 1992
Statistical approaches help in the determination of significant configurations in protein and nucleic acid sequence data. Three recent statistical methods are discussed: (i) score-based sequence analysis that provides a means for characterizing anomalies
S. Karlin, V. Brendel
semanticscholar   +1 more source

Sequence analysis of membrane proteins

1986
The primary structures of proteins can be determined by two distinct methods: directly by sequence analysis of the protein or indirectly by DNA sequence analysis of the corresponding gene or c-DNA. The direct protein sequence analysis methods are strongly influenced by the nature of the protein.
John E. Walker, Ian M. Fearnley
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SEQSEE: a comprehensive program suite for protein sequence analysis

Comput. Appl. Biosci., 1994
SEQSEE (SEQuence SEEker) is a multi-purpose, menu-driven suite of programs designed to provide a fully integrated, state-of-the-art package for the analysis and display of protein sequences and protein databases. It is currently configured to run on most
D. Wishart   +4 more
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Chemical methods of protein sequence analysis

Journal of Chromatography A, 1995
Chemical methods of protein sequence determination are reviewed with particular emphasis on methodology for increasing the sensitivity of amino-terminal sequence analysis and on progress toward the development of an automated procedure for sequential degradation from the carboxy-terminus.
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Analysis of sequence repeats of proteins in the PDB

Computational Biology and Chemistry, 2013
Internal repeats in protein sequences play a significant role in the evolution of protein structure and function. Applications of different bioinformatics tools help in the identification and characterization of these repeats. In the present study, we analyzed sequence repeats in a non-redundant set of proteins available in the Protein Data Bank (PDB).
David Mary Rajathei, Samuel Selvaraj
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