Results 271 to 280 of about 2,214,690 (311)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

circCEP70 encoded protein inhibits the progression of hepatocellular carcinoma. [PDF]

Cell Mol Life Sci
Li L, Xu L, Liao W, Wang P, Xu M, Li B, Zhang M.   +6 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Principles of <i>in vitro</i> selection of ribozymes from random sequence libraries. [PDF]

J R Soc Interface
Higgs PG, Muller UF.
europepmc   +1 more source

Real‐world genomic landscape of colon and rectal cancer

FEBS Open Bio, Volume 15, Issue 4, Page 674-685, April 2025.
We confirmed enrichment of RTK alterations in patients with RAS/BRAF‐wt tumors and of PI3K pathway alterations in RAS/BRAF‐altered tumors with 51 982 real‐world tissue comprehensive genomic profiling (CGP) samples in CRC. In a subset of 140 patients with both tissue and liquid results, the sensitivity of liquid for results found by tissue was 100% when
Markus Schulze, XiaoZhe Wang, Jawad Hamad, Julia C. F. Quintanilha, Lincoln W. Pasquina, Julia F. Hopkins, Juergen Scheuenpflug, Zheng Feng   +7 more
wiley   +1 more source

Rabbit Hepatitis E Virus, Ukraine, 2024. [PDF]

Emerg Infect Dis
Santos-Silva S, Dudnyk Y, Shkromada O, Nascimento MSJ, Gonçalves HMR, Van der Poel WHM, Rivero-Juarez A, Mesquita JR.   +7 more
europepmc   +1 more source

FSH enhances the inflammatory response of macrophages in the knee joint possibly through the NFκB pathway

FEBS Open Bio, Volume 15, Issue 4, Page 622-633, April 2025.
We explored the role of FSH on the synovium and found that FSH was able to mediate the development of osteoarthritis by acting on the FSH receptor (FSHR) to promote the production and release of inflammatory factors through the activation of the NFκB signaling pathway. Previous studies have suggested that women with higher follicle‐stimulating hormone (
Yu Chen, Na Xu, Wen‐wen Zhang, Yan Wang, Tong Su, Yan‐man Zhou, Jin Xu   +6 more
wiley   +1 more source

Long non-coding RNA and mRNA expression profiling of porcine satellite cells using strand-specific RNA-seq. [PDF]

Sci Data
Li C, Cheng X, Li T, Xie X, Li Q, Chen F, Xu H, Zhang P, Xu Y.   +8 more
europepmc   +1 more source

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

FEBS Open Bio, Volume 15, Issue 5, Page 738-753, May 2025.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

De novo RNA base editing in plant organelles with engineered synthetic P-type PPR editing factors. [PDF]

Nucleic Acids Res
Mathieu S, Lesch E, Garcia S, Graindorge S, Schallenberg-Rüdinger M, Hammani K.   +5 more
europepmc   +1 more source