Results 171 to 180 of about 1,274,222 (313)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Sequence analysis

open access: yes, 2013
In quantitative analyses, we analyse nominal and continuous variables, or so we are taught. For example: is a country democratic and how democratic is a country, or is a person poor and how poor is she?
Raab, Marcel
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

A Novel DNA Sequence Compression Method Based on Chaos Game Representation

open access: yes, 2014
Unique signature images derived out of Chaos Game Representation of bio-sequences is an area of research that has been confined to pattern recognition applications.
Arun, K S; Department of Computational Biology and Bioinformatics, University of Kerala, India   +2 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Multiple sequence alignment with the Clustal series of programs

open access: yesNucleic Acids Res., 2003
Chenna Ramu   +6 more
semanticscholar   +1 more source

Biology student Mark Schwartzman

open access: yes, 1982
Biology student Mark Schwartqm taking notes on DNA sequence of genes, UMBC.Student Mark Schwartzman working in the biology lab.From verso: Copyright 1982, by B. J. Wong. Title supplied from caption.
Institutional Advancement, Office of   +1 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

The RNA Ontology (RNAO): An ontology for integrating RNA sequence and structure data

open access: yes, 2009
Biomedical Ontologies are intended to integrate diverse biomedical data to enable intelligent data-mining and facilitate translation of basic research into useful clinical knowledge.
Eric Westhof   +9 more
core  

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