Results 271 to 280 of about 5,890,604 (383)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A colorful legacy of hybridization in wood-warblers includes frequent sharing of carotenoid genes among species and genera. [PDF]

PLoS Biol
Bennett KFP, Wood AW, Baiz MD, Phung LN, Lovette IJ, Toews DPL.   +5 more
europepmc   +1 more source

Synthetic DNA Synthesis and Assembly: Putting the Synthetic in Synthetic Biology.

Cold Spring Harbor Perspectives in Biology, 2017
R. Hughes, A. Ellington
semanticscholar   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

From nematode to Nobel: How community-shared resources fueled the rise of <i>Caenorhabditis elegans</i> as a research organism. [PDF]

Proc Natl Acad Sci U S A
Ambros VR, Chalfie M, Daul AL, Fire AZ, Hall DH, Horvitz HR, Mello CC, Ruvkun G, Schroeder NE, Sternberg PW, Rougvie AE.   +10 more
europepmc   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Memorization bias impacts modeling of alternative conformational states of solute carrier membrane proteins with methods from deep learning. [PDF]

PLoS Comput Biol
Swapna GVT, Dube N, Roth MJ, Montelione GT.   +3 more
europepmc   +1 more source

Difficulty in obtaining the complete mRNA coding sequence at 5′ region (5′ end mRNA artifact): Causes, consequences in biology and medicine and possible solutions for obtaining the actual amino acid sequence of proteins (Review)

, 2017
Lorenza Vitale, Maria Caracausi, Raffaella Casadei, Maria Chiara Pelleri, Allison Piovesan   +4 more
openalex   +2 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Artificial intelligence in structural biology: Preface. [PDF]

Struct Dyn
Phillips GN, Carter CW.
europepmc   +1 more source