Results 311 to 320 of about 5,758,485 (356)

Optimization on construction machinery considering sequence-dependent setup times and personnel fatigue based on the improved gray wolf and whale algorithm. [PDF]

PLoS One
Wang D, Gao B, Zhang L.
europepmc   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Correction to: Ancestral Sequence Reconstruction as a Tool to Detect and Study De Novo Gene Emergence. [PDF]

Genome Biol Evol
europepmc   +1 more source

Genetic analysis and functional assessment of a TGFBR2 variant in micrognathia and cleft palate. [PDF]

PLoS One
Michaels JR, Iyyanar PPR, Husami A, Vontell AM, Brugmann SA, Stottmann RW.   +5 more
europepmc   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Establishment of Cre/LoxP-mediated multifunctional reporter knock-in rats with the CRISPR system. [PDF]

PLoS One
Nakamura K, Ito S, Ohguchi Y, Jimbo T, Wada Y, Nakajima R, Kanou M, Yamana K, Ueda H.   +8 more
europepmc   +1 more source

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

FEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui, Ariel Kushmaro, Hana Barak, Anja Poehlein, Rolf Daniel, Hans‐Jürgen Mägert   +5 more
wiley   +1 more source

Complete genome sequence of <i>Mammaliicoccus lentus</i> (<i>Staphylococcus lentus</i>) strain B3, isolated from mouse early-life gut microbiota. [PDF]

Microbiol Resour Announc
Xu D, Liu Y, Guo S, Wan F.
europepmc   +1 more source

Gauge fixing for sequence-function relationships. [PDF]

PLoS Comput Biol
Posfai A, Zhou J, McCandlish DM, Kinney JB.   +3 more
europepmc   +1 more source