Results 111 to 120 of about 2,731,359 (291)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Generalized difference sequence spaces and their dual spaces [PDF]
, 2007 ÖZETYüksek Lisans TeziGENELLEŞTİRİLMİŞ FARK DİZİ UZAYLARI VE BU UZAYLARINDUALLERİGülhan ÇAKMAKAfyon Kocatepe ÜniversitesiFen Bilimleri EnstitüsüMatematik Anabilim DalıDanışman: Prof. Dr. Fatih NURAYTez altı bölümden oluşmaktadır.
Çakmak, Gülhan
core +1 more source
A new series space |N_{p}^{θ}|(μ) and matrix operators with applications
Kuwait Journal of Science, 2018 The space |N_{p}^{θ}|_{k} of all series summable absolute weighted mean method has recently been introduced and studied by (Sarıgöl 2011), (Sarıgöl 2016) and (Mohapatra and Sarıgöl).
Fadime Gökçe, Mehmet A. Sarıgöl
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Köthe dual of Banach sequence spaces $\ell_p[X]$ $(1\le p<\infty)$ and Grothendieck space
, 1993 summary:In this paper, we show the representation of Köthe dual of Banach sequence spaces $\ell _p[X]$ $(1\leq p< \infty )$ and give a characterization of that the spaces $\ell _p[X]$ $(1< p< \infty )$ are Grothendieck ...
Bu, Qing Ying, Bu, Qingying, Wu, Congxin
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source