Results 111 to 120 of about 2,844,150 (299)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

New Sequence Spaces and Function Spaces on Interval [0,1]

open access: yesJournal of Function Spaces and Applications, 2013
We study the sequence spaces and the spaces of functions defined on interval 0,1 in this paper. By a new summation method of sequences, we find out some new sequence spaces that are interpolating into spaces between ℓp and ℓq and function spaces that are
Cheng-Zhong Xu, Gen-Qi Xu
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

SOME NEW SEQUENCE SPACES DEFINED BY A SEQUENCE OF ORLICZ FUNCTIONS

open access: yes, 2005
In this paper, we introduce some new sequence spaces combining lacunary sequence, invariant means and a sequence of Orlicz functions. We discuss some topological properties and establish some inclusion relations between these spaces.
KARAKAYA, Vatan, Vatan Karakaya
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

A new series space |N_{p}^{θ}|(μ) and matrix operators with applications

open access: yesKuwait Journal of Science, 2018
The space |N_{p}^{θ}|_{k} of all series summable absolute weighted mean method has recently been introduced and studied by (Sarıgöl 2011), (Sarıgöl 2016) and (Mohapatra and Sarıgöl).
Fadime Gökçe, Mehmet A. Sarıgöl
doaj  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Topologies in generalized Orlicz sequence spaces

open access: yes, 2011
In 1994 S. D. Parashar and B. Choudhary defined certain paranorms in some Orlicz sequence spaces of Maddox type. Their ideas are applied later by many authors for topologization of various generalized Orlicz sequence spaces.
Enno Kolk
core   +1 more source

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