Results 231 to 240 of about 28,341 (293)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Recent Advances in the Treatment of Coronary In-Stent Restenosis. [PDF]

open access: yesRev Cardiovasc Med
Sartore L   +6 more
europepmc   +1 more source

A Prospective Randomized Trial Comparing 2 Different Paclitaxel-Coated Balloons in De Novo Coronary Artery Disease. [PDF]

open access: yesJACC Asia
Shin ES   +10 more
europepmc   +1 more source

Drug Coated Balloons Versus Drug-Eluting Stents in Patients With De Novo Coronary Artery Disease. [PDF]

open access: yesCatheter Cardiovasc Interv
O'Callaghan D   +9 more
europepmc   +1 more source

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