Results 41 to 50 of about 168,343 (247)
Algebra and Sequent Calculus for Epistemic Actions
Electronic Notes in Theoretical Computer Science, 2005 AbstractWe introduce an algebraic approach to Dynamic Epistemic Logic. This approach has the advantage that: (i) its semantics is a transparent algebraic object with a minimal set of primitives from which most ingredients of Dynamic Epistemic Logic arise, (ii) it goes with the introduction of non-determinism, (iii) it naturally extends beyond boolean ...
Baltag, Alexandru +2 more
openaire +2 more sources
Simple Decision Procedure for S5 in Standard Cut-Free Sequent Calculus
, 2016 In the paper a decision procedure for S5 is presented which uses a cut-free sequent calculus with additional rules allowing a reduction to normal modal forms. It utilizes the fact that in S5 every formula is equivalent to some 1-degree formula, i.e.
Andrzej Indrzejczak
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A Sequent Calculus for First-Order Logic Formalized in Isabelle/HOL
Italian Conference on Computational Logic, 2021 Asta Halkjær From +2 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A Simple Logical Matrix and Sequent Calculus for Parry’s Logic of Analytic Implication
Studia Logica: An International Journal for Symbolic Logic, 2021 D. Szmuc
semanticscholar +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source