Results 51 to 60 of about 331,537 (286)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Novel use of local analgesia prior to intramuscular magnesium sulphate injection compared to mixed local analgesia with magnesium sulphate to reduce pain: a randomised crossover study in patients being managed for eclampsia and preeclampsia

Frontiers in Pain Research
ObjectiveThe World Health Organization (WHO) recommended addition of local anesthetic to reduce the intense pain of intramuscular injection of 50% Magnesium Sulphate (MgSO4) salt solution has been found to be ineffective.
Modimowame Jamieson, Modimowame Jamieson, Rebecca Luckett, Rebecca Luckett, Rebecca Luckett, G. Justus Hofmeyr, G. Justus Hofmeyr, G. Justus Hofmeyr   +7 more
doaj   +1 more source

Combustion regimes in sequential combustors: Flame propagation and autoignition at elevated temperature and pressure

, 2018
This numerical study investigates the combustion modes in the second stage of a sequential combustor at atmospheric and high pressure. The sequential burner (SB) features a mixing section with fuel injection into a hot vitiated crossflow.
Noiray, Nicolas, Schulz, Oliver
core   +1 more source

Optofluidic fabrication for 3D-shaped particles. [PDF]

, 2015
Complex three-dimensional (3D)-shaped particles could play unique roles in biotechnology, structural mechanics and self-assembly. Current methods of fabricating 3D-shaped particles such as 3D printing, injection moulding or photolithography are limited ...
Chung, Aram J, Di Carlo, Dino, Paulsen, Kevin S   +2 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Amperometric Biosensor for Oxalate Determination in Urine Using Sequential Injection Analysis

Molecules, 2012
An amperometric flow biosensor for oxalate determination in urine samples after enzymatic reaction with oxalate oxidase immobilized on a modified magnetic solid is described.
Enrique Barrado, Yolanda Castrillejo, Veronica Salazar, Prisciliano Hernandez, Jose A. Rodriguez   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The safety and efficacy of sequential intramuscular/oral ziprasidone treatment of acute episode in patients with schizophrenia: a multicenter, open-labeled study

BMC Psychiatry, 2023
Background Ziprasidone mesylate injection is an atypical antipsychotic drug which is recently approved in China. In combination with its oral formulation, sequential therapy with ziprasidone brings new interventions to patients with agitation in the ...
Yaxue Wu, Yanli Li, Weiye Liang, Luyuan Bai, Jianjin Yu, Keqing Li, Yunshu Zhang, Yanmei Guo, Zenglong Liu, Jian Wang, Congpei Zhang, Xijin Wang, Jia Xu, Liping Liu, Juan Li, Fude Yang   +15 more
doaj   +1 more source

Ratiometric spectral imaging for fast tumor detection and chemotherapy monitoring in vivo [PDF]

, 2011
We report a novel in vivo spectral imaging approach to cancer detection and chemotherapy assessment. We describe and characterize a ratiometric spectral imaging and analysis method and evaluate its performance for tumor detection and delineation by ...
Daniel L. Farkas, Harry B. Gray, Jae Youn Hwang, Lali K. Medina-Kauwe, Shonat, Zeev Gross   +5 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source