Results 41 to 50 of about 49,884 (221)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

TXtreme: transformer-based extreme value prediction framework for time series forecasting

Discover Applied Sciences
Time Series Forecasting (TSF) is crucial in various real-world applications such as climate forecasting and electricity demand prediction. Unlike traditional datasets, time series data points are influenced by their past values, necessitating specialized
Hemant Yadav, Amit Thakkar
doaj   +1 more source

Integrating Business Analytics in Educational Decision-Making: A Multifaceted Approach to Enhance Learning Outcomes in EFL Contexts

Mathematics
This study introduces a framework that integrates business analytics into educational decision-making to improve learner engagement and performance in Massive Open Online Courses (MOOCs), focusing on learning environments in English as a Foreign Language
Minsu Cho, Jiyeon Kim, Juhyeon Kim, Kyudong Park   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Intelligent multi-objective optimization of thermal comfort and ventilation performance in stratum ventilation design

Scientific Reports
Stratum ventilation (SV) has emerged as a promising approach for simultaneously addressing indoor thermal comfort, airflow effectiveness, and energy efficiency.
Nadia Ghezaiel Hammouda, Zakarya Ahmed, Ihab Omar, As’ad Alizadeh, Narinderjit Singh Sawaran Singh, Borhen Louhichi, Walid Aich, Banafshe Hamidi   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

QPCA-CLT Net: An Integrated CNN-LSTM-Transformer Framework with Progressive Dimensionality Reduction and Trend Smoothing for Enhanced Multivariate Time Series Forecasting

International Journal of Computational Intelligence Systems
Forecasting Multivariate Time Series (MTS) data with high accuracy is desired for various decision-making tasks in meteorology, healthcare, and financial analytics.
Yuvaraja Boddu, A. Manimaran, Arunkumar Balakrishnan, S. Anbukkarasi   +3 more
doaj   +1 more source

A Reinforcement Learning and Unsupervised Clustering-Based Method for Automated Driving Cycle Construction for Fuel Cell Light-Duty Trucks

World Electric Vehicle Journal
Addressing the lack of high-fidelity test cycles for fuel cell light-duty trucks, this paper proposes an automated driving cycle construction method that integrates unsupervised clustering and reinforcement learning.
Jinbiao Shi, Weibo Zheng, Ran Huo, Po Hong, Bing Li, Pingwen Ming   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source